142667-63-8

Basic information

• Product Name: Pyridine, 1-(3-butynyl)-1,2,3,6-tetrahydro-4-phenyl-
• CAS NO: 142667-63-8
• Molecular Formula: C15H17N
• Molecular Weight: 211.307
• Mol File: 142667-63-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Pyridine, 1-(3-butynyl)-1,2,3,6-tetrahydro-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 1-(3-butynyl)-1,2,3,6-tetrahydro-4-phenyl-(142667-63-8)
• EPA Substance Registry System: Pyridine, 1-(3-butynyl)-1,2,3,6-tetrahydro-4-phenyl-(142667-63-8)

Safety Data

• Hazardous Substances Data: 142667-63-8(Hazardous Substances Data)

Upstream product

• 10338-69-9 1,2,3,6-tetrahydro-4-phenylpyridine 
• 23418-85-1 3-butyn-1-yl p-toluenesulfonate 

Downstream Products

• 173840-28-3 1,2,3,6-tetrahydro-1-[4-(5-nitro-2-pyridinyl)-3-butynyl]-4-phenylpyridine 
• 173840-29-4 1,2,3,6-Tetrahydro-1-[4-(4-nitrophenyl)-3-butynyl]-4-phenylpyridine 
• 142667-46-7 6-[4-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)-1-butynyl]-3-pyridinamine 

Relevant articles and documents

Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: Synthesis and structure-activity relationships

A novel series of aryl 1-but-3-ynyl-4-phenyl-1,2,3,6- tetrahydropyridines with dopaminergic activity is described. The structure- activity relationships of this series were studied by synthesis of analogs and evaluation of their affinities for the dopamine (DA) D2 receptor and inhibition of locomotor activity (LMA) in rodents. The basic amine, alkyne chain length, and aryl groups were varied. Compounds having a 4-phenyl- 1,2,3,6-tetrahydropyridine and an aryl group with hydrogen-bonding substituents separated by a butynyl chain were found to have the most potent dopaminergic activity. Several compounds that were found to have exceptional in vivo activity in LMA inhibition in rodents were evaluated for additional pharmacological activity including binding affinities for other DA receptor subtypes as well as effects on brain DA synthesis, DA neuronal firing, and conditioned avoidance responding in squirrel monkeys.