1428332-77-7

Basic information

• Product Name: C₂₂H₁₈N₂O₄S
• CAS NO: 1428332-77-7
• Molecular Weight: 406.462
• Mol File: 1428332-77-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₁₈N₂O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₁₈N₂O₄S(1428332-77-7)
• EPA Substance Registry System: C₂₂H₁₈N₂O₄S(1428332-77-7)

Safety Data

• Hazardous Substances Data: 1428332-77-7(Hazardous Substances Data)

Upstream product

• 83051-28-9 5-amino-2-benzyl-2,3-dihydro-1H-isoindole-1,3-dione 
• 98-59-9 p-toluenesulfonyl chloride 
• 60283-84-3 2-benzyl-5-nitroisoindoline-1,3-dione 
• 89-40-7 4-nitrophthalimide 
• 136918-14-4 phthalimide 

Relevant articles and documents

A new series of N2-substituted-5-(p-toluenesulfonylamino)phthalimide analogues as α-glucosidase inhibitors

Several members of a new family of non-sugar-type α-glycosidase inhibitors, bearing a 5-(p-toluenesulfonylamino)phthalimide moiety and various substituent at the N2 position, were synthesized and their activities were investigated. The newly synthesized compounds displayed different inhibition profile towards yeast α-glycosidase and rat intestinal α-glycosidase. Almost all the compounds had strong inhibitory activities against yeast α-glycosidase. Regarding rat intestinal α-glycosidase, only analogs with N2-aromatic substituents displayed varying degrees of inhibitory activities on rat intestinal maltase and lactase and nearly all compounds showed no inhibition against rat intestinal α-amylase. Structure-activity relationship studies indicated that 5-(p- toluenesulfonylamino)phthalimide moiety is a favorable scaffold to exert the α-glucosidase inhibitory activity and substituents at the N2 position have considerable influence on the efficacy of the inhibition activities.