14297-39-3

Basic information

• Product Name: 1-(chloromethyl)-4-(phenylmethyl)benzene
• Synonyms: 1-(chloromethyl)-4-(phenylmethyl)benzene;[4-(Chloromethyl)phenyl]phenylmethane;1-(Chloromethyl)-4-benzylbenzene;4-Benzylbenzyl chloride;4-Benzyl-α-chlorotoluene;1-Benzyl-4-(chloromethyl)benzene
• CAS NO: 14297-39-3
• Molecular Formula: C₁₄H₁₃Cl
• Molecular Weight: 216.70602
• EINECS: 238-226-9
• Mol File: 14297-39-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 324.8 °C at 760 mmHg
• Flash Point: 144.5 °C
• Appearance: /
• Density: 1.102 g/cm³
• Vapor Pressure: 0.000455mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(chloromethyl)-4-(phenylmethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(chloromethyl)-4-(phenylmethyl)benzene(14297-39-3)
• EPA Substance Registry System: 1-(chloromethyl)-4-(phenylmethyl)benzene(14297-39-3)

Safety Data

• Hazardous Substances Data: 14297-39-3(Hazardous Substances Data)

Usage

General Description

1-(Chloromethyl)-4-(phenylmethyl)benzene is a chemical compound with molecular formula C15H15Cl. This organic compound falls into the category of compounds known as benzene and substituted derivatives, which are aromatic compounds containing one monocyclic ring. Most often, it is a synthetic compound employed within chemical research or the manufacture of other complex chemicals. There are no public records of this compound being employed within biological or health specificity. It is recommended to be stored in a cool, dry place in tightly closed container. As with all chemicals, handling should be done with appropriate care and protective equipment.

InChI:InChI=1/C14H13Cl/c15-11-14-8-6-13(7-9-14)10-12-4-2-1-3-5-12/h1-9H,10-11H2

Upstream product

• 100-44-7 benzyl chloride 
• 563-47-3 3-Chloro-2-methylpropene 
• 7446-70-0 aluminium trichloride 
• 98-95-3 nitrobenzene 
• 98-80-6 phenylboronic acid 
• 1352919-05-1 N-((4-(chloromethyl)benzyl)oxy)-N-methylacetamide 
• 71-43-2 benzene 
• 620-86-0 4-Benzylbenzoic acid 
• 611-95-0 4-carboxybenzophenone 
• 35714-20-6 4-benzylbenzyl alcohol 
• 50-00-0 formaldehyd 
• 101-81-5 Diphenylmethane 

Downstream Products

• 708968-59-6 S-(4-benzyl-benzyl)-isothiourea 
• 101096-72-4 4-benzyl-1-cyanomethylbenzene 
• 262862-92-0 4-hydroxy-1-(4-benzylbenzyl)pyrrolidin-2-one 
• 18908-82-2 3-{4-[4-(4-{4-[4-(2-Ethoxycarbonyl-ethyl)-benzyl]-benzoyl}-benzoyl)-benzyl]-phenyl}-propionic acid ethyl ester 
• 18908-92-4 3-{4-[4-(4-{4-[4-(2-Ethoxycarbonyl-ethyl)-benzyl]-benzyl}-benzyl)-benzyl]-phenyl}-propionic acid ethyl ester 
• 72404-48-9 2-Acetylamino-2-(4-benzyl-benzyl)-malonic acid 
• 100887-07-8 (4-benzylphenyl)(methyl) sulfane 
• 60313-20-4 4-benzyl-bibenzyl-α-ol 
• 655243-56-4 5,6-bis-(4-benzyl-benzyloxy)-3-chloro-benzo[b]thiophene-2-carboxylic acid methyl ester 
• 250332-40-2 trans-4'-benzyl-5-styrylfuran 
• 72404-47-8 2-Acetylamino-2-(4-benzyl-benzyl)-malonic acid diethyl ester 
• 18908-76-4 ethyl 3-(4-benzylphenyl)propanoate 
• 115829-23-7 2,6-dibenzyl-anthracene 
• 35714-20-6 4-benzylbenzyl alcohol 

Relevant articles and documents

Meta selectivity in the Friedel-Crafts reaction induced by a faujasite-type zeolite

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Method for preparing coupling arene from aryl halide by ionizing, discharging and coupling

The invention discloses a method for preparing coupling arene from aryl halide by ionizing, discharging and coupling. The method comprises the following steps: placing a magnetic stirrer into a three-necked flask and adding aryl halide occupying 1/2 flask, thereby finishing the assembling of an ionizing reaction device; placing the ionizing reaction device into an oil bath pan, introducing inert gas into a reaction system, removing air from the reaction system, starting stirring and heating in the oil bath pan to make aryl halide flow back, and meanwhile, introducing water into a ball-shaped condensation pipe for cooling; starting a high-voltage power generator, and introducing powerful arc generated into the three-necked flask through a metal electrode, thereby ionizing and decomposing aryl halide steam and generating a coupling arene compound; stopping ionizing and heating when solids are separated or the backflow of aryl halide is slowed in a round-bottom flask, and then ending the reaction; recrystallizing or performing reduced pressure distillation purification on the coupling arene product in the flask, thereby acquiring the coupling arene product. The method disclosed by the invention has the advantages of low cost, high efficiency, environmental protection, and the like.

Friedel-crafts benzylation of activated and deactivated arenes

NO going back makes possible facile Friedel-Crafts benzylations with moderate reaction temperatures, simple reaction workups, and improved substrate scope for the formation of synthetically important diarylmethanes (see scheme). Upon complexation with BF3?OEt2, hydroxamates serve as reversible leaving groups that stabilize highly reactive carbocations. Even deactivated arenes and electron-deficient benzylhydroxamates react cleanly under these conditions.