142998-47-8

Basic information

• Product Name: Salvianolic acid D
• Synonyms: Salvianolic acid D;(alphaR)-alpha-[[(2E)-3-[2-(Carboxymethyl)-3,4-dihydroxyphenyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxybenzenepropanoic acid;Benzenepropanoic acid, a-[[(2E)-3-[2-(carboxymethyl)-3,4-dihydroxyphenyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-,(aR)-
• CAS NO: 142998-47-8
• Molecular Formula: C20H18O10
• Molecular Weight: 418.35092
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 142998-47-8.mol

Chemical Properties

• Appearance: /
• Density: 1.607
• CAS DataBase Reference: Salvianolic acid D(CAS DataBase Reference)
• NIST Chemistry Reference: Salvianolic acid D(142998-47-8)
• EPA Substance Registry System: Salvianolic acid D(142998-47-8)

Safety Data

• Hazardous Substances Data: 142998-47-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Salvianolic acid D is used as a therapeutic agent for the treatment of cardiovascular and cerebrovascular diseases. It demonstrates potent antioxidant, anti-inflammatory, and vasodilatory effects, which contribute to its protective role in maintaining vascular health and improving blood circulation.
Used in Anticancer Applications:
Salvianolic acid D is employed as an anticancer agent, particularly against various types of cancer. It modulates several oncological signaling pathways, exerting inhibitory effects on tumor growth and progression. Additionally, it demonstrates synergistic anticancer effects when combined with conventional chemotherapeutic drugs, enhancing chemo-sensitivity and efficacy in resistant cases.
Used in Drug Delivery Systems:
To overcome the limitations of Salvianolic acid D, such as poor solubility and bioavailability, novel drug delivery systems have been developed. These systems, including various organic and metallic nanoparticles, serve as carriers for Salvianolic acid D, aiming to improve its delivery, bioavailability, and therapeutic outcomes.

Upstream product

• 55757-13-6 salvianolic acid B 

Relevant articles and documents

Method for preparing salvianolic acid A

The invention discloses a method for preparing salvianolic acid A. The method includes the following steps that firstly, salvianolic acid B is prepared into a solution with the concentration of 35-45 mg/mL by means of NaOH or NaHCO3 with the pH value of 3.5-4.5, the solution is placed in a subcritical water reaction kettle, after the temperature of a heating furnace reaches 170-190 DEG C and is stabilized, the reaction kettle is placed into the heating furnace, the reaction kettle is taken out after 50-70 min and placed in ice water bath or cold water to be cooled, the liquid is taken out and subjected to freeze-drying, and a crude product rich in salvianolic acid A is obtained; secondly, salvianolic acid A is separated and purified by means of high-speed countercurrent chromatography, wherein a solvent system is prepared from petroleum ether, ethyl acetate, n-butyl alcohol and water according to the ratio of 2:3:1:9, 10 mM of trifluoroacetic acid is added to an upper phase to form a stationary phase, 10 mM ammonia water is a lower phase and serves as a mobile phase, the volume of a high-speed countercurrent chromatography column is 200-400 mL, the sample loading amount is 1.0-1.2 g, the rotation speed is 600-1000 rpm, the flow speed is 1-4 mL/min, and the detection wavelength is 280 nm. The method is low in cost, easy to operate and high in efficiency, salvianolic acid crude extracts can be converted on a large scale, and a salvianolic acid A monomeric compound with the purity higher than 98% is separated and prepared.

Chemical conversions of salvianolic acid B by decoction in aqueous solution

Salvianolic acid B (Sal B) is the most abundant phenolic compound in Salvia miltiorrhiza, which has been widely used for the treatment of cardiovascular diseases in Oriental medicine. To elucidate structure of the converted compounds of Sal B by decoction