143722-28-5

Basic information

• Product Name: 5-(4'-Methanesulfonyloxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole
• Synonyms: 5-(4'-Methanesulfonyloxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole
• CAS NO: 143722-28-5
• Molecular Weight: 572.687
• Mol File: 143722-28-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(4'-Methanesulfonyloxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4'-Methanesulfonyloxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole(143722-28-5)
• EPA Substance Registry System: 5-(4'-Methanesulfonyloxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole(143722-28-5)

Safety Data

• Hazardous Substances Data: 143722-28-5(Hazardous Substances Data)

Upstream product

• 1711-02-0 4-iodobenzoic acid chloride 
• 143722-25-2 2-(2'-Triphenylmethyl-2'H-tetrazol-5'-yl)-phenylboronic acid 
• 873-75-6 4-bromobenzenemethanol 
• 15290-29-6 4-(trimethylsilyl)benzoic acid 
• 6999-03-7 1-bromo-4-(trimethylsilyl)benzene 
• 18282-51-4 4-iodo-benzyl alcohol 
• 106-37-6 1.4-dibromobenzene 
• 619-58-9 4-iodobenzoic acid 
• 124-63-0 methanesulfonyl chloride 
• 135050-95-2 2'-<2-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-methanol 
• 157756-27-9 5-<4'-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl><1,1'-biphenyl>-2-yl>-2-(triphenylmethyl)-1H-tetrazole 
• 147283-96-3 4-(tert-butyldimethylsiloxymethyl)iodobenzene 

Downstream Products

• 150438-02-1 CI 996 
• 1027968-99-5 2-Propyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-5-[2-(2,2,2-trifluoro-acetyl)-pyrrol-1-yl]-3H-imidazole-4-carboxylic acid ethyl ester 
• 133909-99-6 2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol 
• 1026262-77-0 2-Propyl-5-[2-(2,2,2-trifluoro-acetyl)-pyrrol-1-yl]-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester 

Relevant articles and documents

Model reactions targeted at the synthesis of carbon-14 labeled CI-996, a potent antagonist of angiotensin II receptor (1)

A reaction sequence suitable for the preparation of an analog of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl-4-[2-(tr ifluoroacetyl)-1H-pyrrol-1-yl]-1H-imidazole-5-carboxylic acid, with 14C at the methylene bridge was developed. The would-be labeled fragment (12) was derived from 4-iodobenzenemethanol (6) which itself was constructed from 1,4-dibromobenzene by the application of silicon chemistry. Pd(o) catalyzed coupling of TBDMS protected 6 and a tetrazole borate 10 gave the compound 12 which upon further transformation to the mesylate 13, N-alkylated an imidazole to furnish target compound.

Tetrazolylphenylboronic acid intermediates for the synthesis of AII receptor antagonists

Novel tetrazolylphenylboronic acids, methods for their preparation, and their use in the syntheses of angiotensin II receptor antagonists are disclosed.