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1437869-76-5

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1437869-76-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1437869-76-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,3,7,8,6 and 9 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1437869-76:
(9*1)+(8*4)+(7*3)+(6*7)+(5*8)+(4*6)+(3*9)+(2*7)+(1*6)=215
215 % 10 = 5
So 1437869-76-5 is a valid CAS Registry Number.

1437869-76-5Downstream Products

1437869-76-5Relevant articles and documents

Design, synthesis and biological evaluation of novel 3,4,5-trisubstituted aminothiophenes as inhibitors of p53-MDM2 interaction. Part 2

Wang, Weisi,Lv, Dan,Qiu, Ni,Zhang, Lei,Hu, Chunqi,Hu, Yongzhou

, p. 2886 - 2894 (2013/06/27)

Five series of novel 3,4,5-trisubstituted aminothiophene derivatives and analogs were designed and synthesized based on our previous studies. All target compounds were evaluated for their p53-MDM2 binding inhibitory activities and anti-proliferation activities against A549 and PC3 tumor cell lines. Twelve compounds displayed comparable p53-MDM2 binding inhibitory activities to that of Nutlin-3. Among them, compound 7a exhibited marked binding affinity (IC 50 = 0.086 μM). In addition, most target compounds showed potent anti-proliferation activities with IC50 values at low micromolar level. A good selective profile for wild-type p53 expression cell line was also observed. Molecular docking analysis was performed as well to predict possible binding modes of target compounds with MDM2.

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