1437869-76-5

Basic information

• Product Name: C₂₁H₁₈BrClN₂OS
• Synonyms: C₂₁H₁₈BrClN₂OS
• CAS NO: 1437869-76-5
• Molecular Weight: 461.81
• Mol File: 1437869-76-5.mol

Chemical Properties

• CAS DataBase Reference: C₂₁H₁₈BrClN₂OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₁₈BrClN₂OS(1437869-76-5)
• EPA Substance Registry System: C₂₁H₁₈BrClN₂OS(1437869-76-5)

Safety Data

• Hazardous Substances Data: 1437869-76-5(Hazardous Substances Data)

Upstream product

• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 23566-00-9 2-(4-bromophenyl)-1-(4-chlorophenyl)ethan-1-one 
• 37859-24-8 2-(4-bromophenyl)acetyl chloride 

Relevant articles and documents

Design, synthesis and biological evaluation of novel 3,4,5-trisubstituted aminothiophenes as inhibitors of p53-MDM2 interaction. Part 2

Five series of novel 3,4,5-trisubstituted aminothiophene derivatives and analogs were designed and synthesized based on our previous studies. All target compounds were evaluated for their p53-MDM2 binding inhibitory activities and anti-proliferation activities against A549 and PC3 tumor cell lines. Twelve compounds displayed comparable p53-MDM2 binding inhibitory activities to that of Nutlin-3. Among them, compound 7a exhibited marked binding affinity (IC 50 = 0.086 μM). In addition, most target compounds showed potent anti-proliferation activities with IC50 values at low micromolar level. A good selective profile for wild-type p53 expression cell line was also observed. Molecular docking analysis was performed as well to predict possible binding modes of target compounds with MDM2.