143843-07-6Relevant articles and documents
Synthesis of biologically active taxol analogues with modified phenylisoserine side chains
Georg,Cheruvallath,Himes,Mejillano,Burke
, p. 4230 - 4237 (2007/10/02)
Taxol (1) is a highly potent antitumor agent, exerting its mechanism of action by promoting the assembly of stable microtubules in cells. We are reporting on the first synthesis and biological evaluation of taxol derivatives with substituted phenyl rings