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1440426-62-9

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1440426-62-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1440426-62-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,0,4,2 and 6 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1440426-62:
(9*1)+(8*4)+(7*4)+(6*0)+(5*4)+(4*2)+(3*6)+(2*6)+(1*2)=129
129 % 10 = 9
So 1440426-62-9 is a valid CAS Registry Number.

1440426-62-9Relevant articles and documents

Bispyrimidines as potent histamine H4 receptor ligands: Delineation of structure-activity relationships and detailed H4 receptor binding mode

Engelhardt, Harald,Schultes, Sabine,De Graaf, Chris,Nijmeijer, Saskia,Vischer, Henry F.,Zuiderveld, Obbe P.,Dobler, Julia,Stachurski, Katharina,Mayer, Moriz,Arnhof, Heribert,Scharn, Dirk,Haaksma, Eric E. J.,De Esch, Iwan J. P.,Leurs, Rob

supporting information, p. 4264 - 4276 (2013/07/19)

The basic methylpiperazine moiety is considered a necessary substructure for high histamine H4 receptor (H4R) affinity. This moiety is however also the metabolic hot spot for various classes of H4R ligands (e.g., indolcarboxamides and pyrimidines). We set out to investigate whether mildly basic 2-aminopyrimidines in combination with the appropriate linker can serve as a replacement for the methylpiperazine moiety. In the series of 2-aminopyrimidines, the introduction of an additional 2-aminopyrimidine moiety in combination with the appropriate linker lead to bispyrimidines displaying pKi values for binding the human H4R up to 8.2. Furthermore, the methylpiperazine replacement results in compounds with improved metabolic properties. The attempt to transfer the knowledge generated in the class of bispyrimidines to the indolecarboxamides failed. Combining the derived structure-activity relationships with homology modeling leads to new detailed insights in the molecular aspects of ligand-H4R binding in general and the binding mode of the described bispyrimidines in specific.

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