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Cas Database

1440522-39-3

1440522-39-3

Identification

  • Product Name:C45H53NO13

  • CAS Number: 1440522-39-3

  • EINECS:

  • Molecular Weight:815.915

  • Molecular Formula: C45H53NO13

  • HS Code:

  • Mol File:1440522-39-3.mol

Synonyms:C45H53NO13

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Relevant articles and documentsAll total 1 Articles be found

Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation

Zhao, Yu,Su, Jia,Goto, Masuo,Morris-Natschke, Susan L.,Li, Yan,Zhao, Qin-Shi,Yao, Zhu-Jun,Lee, Kuo-Hsiung

, p. 4749 - 4757 (2013/07/19)

Taxchinin A, with a 11(15→1)-abeo-taxane skeleton, is a major, but inactive taxoid contained in leaves of Taxus chinensis. In our design of dual-functional antitumor abeo-taxane derivatives, two fragments from antitumor agents with different molecular tar

Process route upstream and downstream products

Process route

C<sub>49</sub>H<sub>61</sub>NO<sub>14</sub>

C49H61NO14

C<sub>45</sub>H<sub>53</sub>NO<sub>13</sub>
1440522-39-3

C45H53NO13

Conditions
Conditions Yield
With hydrogenchloride; In tetrahydrofuran; water; at 0 - 20 ℃; for 4h; Inert atmosphere;
44%
C<sub>51</sub>H<sub>65</sub>NO<sub>16</sub>

C51H65NO16

C<sub>45</sub>H<sub>53</sub>NO<sub>13</sub>
1440522-39-3

C45H53NO13

C<sub>47</sub>H<sub>57</sub>NO<sub>15</sub>
1440522-41-7

C47H57NO15

Conditions
Conditions Yield
With hydrogenchloride; In tetrahydrofuran; water; at 0 - 20 ℃; for 4h; Inert atmosphere;
25%
34%
C<sub>39</sub>H<sub>54</sub>O<sub>11</sub>Si
1035113-20-2

C39H54O11Si

C<sub>45</sub>H<sub>53</sub>NO<sub>13</sub>
1440522-39-3

C45H53NO13

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere
2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: hydrogenchloride / water; tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
With hydrogenchloride; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; In tetrahydrofuran; water;
C<sub>39</sub>H<sub>56</sub>O<sub>11</sub>Si
1035113-18-8

C39H56O11Si

C<sub>45</sub>H<sub>53</sub>NO<sub>13</sub>
1440522-39-3

C45H53NO13

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1.1: pyridinium chlorochromate / dichloromethane / 8 h / 20 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere
3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
3.2: Inert atmosphere
4.1: hydrogenchloride / water; tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
With hydrogenchloride; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; water;
acetoxybrevifoliol
146621-74-1

acetoxybrevifoliol

C<sub>45</sub>H<sub>53</sub>NO<sub>13</sub>
1440522-39-3

C45H53NO13

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 10 h / -40 °C / Inert atmosphere
2.1: pyridinium chlorochromate / dichloromethane / 8 h / 20 °C / Inert atmosphere
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere
4.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
4.2: Inert atmosphere
5.1: hydrogenchloride / water; tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
With 1H-imidazole; hydrogenchloride; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
acetoxybrevifoliol
146621-74-1

acetoxybrevifoliol

C<sub>45</sub>H<sub>53</sub>NO<sub>13</sub>
1440522-39-3

C45H53NO13

C<sub>47</sub>H<sub>57</sub>NO<sub>15</sub>
1440522-41-7

C47H57NO15

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 10 h / -40 °C / Inert atmosphere
2.1: pyridinium chlorochromate / dichloromethane / 8 h / 20 °C / Inert atmosphere
3.1: hydrogen fluoride; pyridine / water; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
4.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
4.2: Inert atmosphere
5.1: hydrogenchloride / water; tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
With pyridine; 1H-imidazole; hydrogenchloride; hydrogen fluoride; sodium hexamethyldisilazane; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
C<sub>39</sub>H<sub>54</sub>O<sub>11</sub>Si
1035113-20-2

C39H54O11Si

C<sub>45</sub>H<sub>53</sub>NO<sub>13</sub>
1440522-39-3

C45H53NO13

C<sub>47</sub>H<sub>57</sub>NO<sub>15</sub>
1440522-41-7

C47H57NO15

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1.1: hydrogen fluoride; pyridine / water; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: hydrogenchloride / water; tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
With pyridine; hydrogenchloride; hydrogen fluoride; sodium hexamethyldisilazane; In tetrahydrofuran; water;
C<sub>39</sub>H<sub>56</sub>O<sub>11</sub>Si
1035113-18-8

C39H56O11Si

C<sub>45</sub>H<sub>53</sub>NO<sub>13</sub>
1440522-39-3

C45H53NO13

C<sub>47</sub>H<sub>57</sub>NO<sub>15</sub>
1440522-41-7

C47H57NO15

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1.1: pyridinium chlorochromate / dichloromethane / 8 h / 20 °C / Inert atmosphere
2.1: hydrogen fluoride; pyridine / water; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
3.2: Inert atmosphere
4.1: hydrogenchloride / water; tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
With pyridine; hydrogenchloride; hydrogen fluoride; sodium hexamethyldisilazane; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; water;
C<sub>33</sub>H<sub>40</sub>O<sub>11</sub>
1035113-22-4

C33H40O11

1-tert-butoxycarbonyl-(3R,4S)-3-EEO-4-phenylazetidin-2-one
201856-57-7,152089-12-8

1-tert-butoxycarbonyl-(3R,4S)-3-EEO-4-phenylazetidin-2-one

C<sub>45</sub>H<sub>53</sub>NO<sub>13</sub>
1440522-39-3

C45H53NO13

C<sub>47</sub>H<sub>57</sub>NO<sub>15</sub>
1440522-41-7

C47H57NO15

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: hydrogenchloride / water; tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
With hydrogenchloride; sodium hexamethyldisilazane; In tetrahydrofuran; water;

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