144060-67-3

Basic information

• Product Name: 2-(4-Hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylic acid ethyl ester
• Synonyms: 2-(4-Hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylic acid ethyl ester;Ethyl 2-(4-hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarbonate;Ethyl 2-(4-hydroxy-3-nitrophenyl)-4-methylthiazole-5-carboxylate;5-Thiazolecarboxylic acid,2-(4-hydroxy-3-nitrophenyl)-4-methyl-,ethyl ester
• CAS NO: 144060-67-3
• Molecular Formula: C₁₃H₁₂N₂O₅S
• Molecular Weight: 308.31
• Mol File: 144060-67-3.mol

Chemical Properties

• Boiling Point: 453.044 °C at 760 mmHg
• Flash Point: 227.793 °C
• Appearance: /
• Density: 1.411
• Vapor Pressure: 7.95E-09mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-Hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylic acid ethyl ester(144060-67-3)
• EPA Substance Registry System: 2-(4-Hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylic acid ethyl ester(144060-67-3)

Safety Data

• Hazardous Substances Data: 144060-67-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylic acid ethyl ester is used as a potential pharmaceutical agent for its possible biological activities. The presence of functional groups such as the hydroxyl and nitro groups on the phenyl ring, along with the thiazole and ethyl ester moieties, suggests that this compound could interact with biological targets, potentially leading to therapeutic effects.
Further research and testing are required to elucidate the specific properties and uses of 2-(4-Hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylic acid ethyl ester, including its pharmacological profile, safety, and efficacy. Depending on the outcomes of such studies, this compound may find applications in the development of new drugs for treating various diseases and conditions.

InChI:InChI=1/C13H12N2O5S/c1-3-20-13(17)11-7(2)14-12(21-11)8-4-5-10(16)9(6-8)15(18)19/h4-6,16H,3H2,1-2H3

Upstream product

• 638-07-3 ethyl (2-chloroaceto)acetate 
• 767-00-0 4-cyanophenol 
• 161797-99-5 (2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester) 

Downstream Products

• 144060-76-4 ethyl 2-(3-chloro-4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate 
• 144060-79-7 2-(3-bromo-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester 

Relevant articles and documents

A NOVEL PROCESS FOR PREPARATION OF ETHYL 2-(4-HYDROXY-3-NITROPHENYL)-4-METHYL-5-THIAZOLECARBOXYLATE

A novel process for preparation of ethyl 2-(4-hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate is disclosed. The process involves reaction of ethyl 2-(4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate with metal nitrate in presence of acid chloride and N,N-Dimethylformamide to produce title compound with improved yield and economics than that reported in the prior art.

2-arylthiazole derivatives and pharmaceutical composition thereof

Pharmaceutical compositions for treating gout or hyperuricemia and containing a new categorized compound, i.e. 2-arylthiazole derivatives, as an active ingredient, are provided. The 2-arylthiazole derivatives in the present invention are represented by the following formula (I): STR1 wherein Ar is an unsubstituted or substituted pyridyl, thienyl, furyl, naphthyl or phenyl group; X is a hydrogen atom, alkyl group or carboxyl group which may be protected, and Y is a hydrogen atom, alkyl group, or a hydroxyl or carbonyl group which may be protected. Furthermore, novel compounds included in the 2-arylthiazole derivatives and pharmaceutically acceptable salts thereof are provided.