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(2R,5R)-1,6-Diphenyl-2,5-hexanediamine, also known as d-Phenylglycine, is a chiral amine compound characterized by its two phenyl groups and a six-carbon chain diamine structure. This specific stereochemistry, with the (2R,5R) configuration, is crucial for its reactivity and potential applications in various chemical processes. It is primarily utilized in the synthesis of pharmaceuticals and organic materials, making it a valuable intermediate in the production of complex organic molecules.

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  • 144186-34-5 Structure
  • Basic information

    1. Product Name: (2R,5R)-1,6-Diphenyl-2,5-hexanediamine
    2. Synonyms: (2R,5R)-1,6-Diphenyl-2,5-hexanediamine;1,6-diphenylhexane-2,5-diamine
    3. CAS NO:144186-34-5
    4. Molecular Formula: C18H24N2
    5. Molecular Weight: 268.39656
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 144186-34-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 439.9±45.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.044±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 10.95±0.35(Predicted)
    10. CAS DataBase Reference: (2R,5R)-1,6-Diphenyl-2,5-hexanediamine(CAS DataBase Reference)
    11. NIST Chemistry Reference: (2R,5R)-1,6-Diphenyl-2,5-hexanediamine(144186-34-5)
    12. EPA Substance Registry System: (2R,5R)-1,6-Diphenyl-2,5-hexanediamine(144186-34-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 144186-34-5(Hazardous Substances Data)

144186-34-5 Usage

Uses

Used in Pharmaceutical Industry:
(2R,5R)-1,6-Diphenyl-2,5-hexanediamine is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the formation of complex organic molecules. Its specific stereochemistry allows for targeted reactions and the creation of compounds with desired therapeutic properties.
Used in Organic Material Synthesis:
In the field of organic material synthesis, (2R,5R)-1,6-Diphenyl-2,5-hexanediamine is used as a building block for creating a range of organic compounds. Its unique structure and reactivity enable the development of new materials with specific properties for various applications.
Used in Polymer Production:
(2R,5R)-1,6-Diphenyl-2,5-hexanediamine is used as a monomer or a component in the production of polymers. Its incorporation into polymer chains can influence the polymer's properties, such as strength, flexibility, and chemical resistance, making it suitable for specific industrial applications.
Used in Industrial Material Production:
(2R,5R)-1,6-Diphenyl-2,5-hexanediamine is also utilized in the production of various industrial materials, where its unique structure and properties can enhance the performance of the final product. Its applications in this industry can range from improving material characteristics to enabling new functionalities.

Check Digit Verification of cas no

The CAS Registry Mumber 144186-34-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,1,8 and 6 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 144186-34:
(8*1)+(7*4)+(6*4)+(5*1)+(4*8)+(3*6)+(2*3)+(1*4)=125
125 % 10 = 5
So 144186-34-5 is a valid CAS Registry Number.

144186-34-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (2R,5R)-1,6-diphenylhexane-2,5-diamine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:144186-34-5 SDS

144186-34-5Relevant articles and documents

For the synthesis of anti-aids agent potentiators cobicistat intermediates

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Paragraph 0068; 0069; 0070; 0071, (2016/10/07)

The invention relates to a method for synthesizing a novel midbody compound I for synthesizing an anti-AIDS medicine reinforcing agent cobicistat and further discloses a method for synthesizing (2R,5R)-1,6-diphenyl-2,5-hexamethylendiamine by using the com

METHODS AND INTERMEDIATES FOR PREPARING PHARMACEUTICAL AGENTS

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Page/Page column 75-77, (2013/08/15)

Methods and intermediates useful for preparing a compound of formula I and salts thereof.

METHODS AND INTERMEDIATES FOR PREPARING PHARMACEUTICAL AGENTS

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Page/Page column 18-19, (2010/10/19)

The invention provides methods and intermediates that are useful for preparing a compound of formula I: and salts thereof.

A novel and efficient synthesis of chiral C2-symmetric 1,4-diamines

Xu, Lianhong,Desai, Manoj C.,Liu, Hongtao

scheme or table, p. 552 - 554 (2009/05/07)

A novel and efficient method for synthesis of (R,R)- and (S,S)-C2-symmetric 1,4-diamines was established. The key steps are a combination of Pinacol Coupling and Corey-Winter olefination.

MODULATORS OF PHARMACOKINETIC PROPERTIES OF THERAPEUTICS

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Page/Page column 197-198, (2008/06/13)

The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.

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