144220-93-9

Basic information

• Product Name: 2(3H)-Benzoxazolone, 6-(2-fluorobenzoyl)-
• CAS NO: 144220-93-9
• Molecular Formula: C14H8FNO3
• Molecular Weight: 257.221
• Mol File: 144220-93-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2(3H)-Benzoxazolone, 6-(2-fluorobenzoyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-Benzoxazolone, 6-(2-fluorobenzoyl)-(144220-93-9)
• EPA Substance Registry System: 2(3H)-Benzoxazolone, 6-(2-fluorobenzoyl)-(144220-93-9)

Safety Data

• Hazardous Substances Data: 144220-93-9(Hazardous Substances Data)

Upstream product

• 59-49-4 2-Benzoxazolinone 
• 445-29-4 o-fluoro-benzoic acid 

Downstream Products

• 144220-77-9 6-(2-Fluoro-benzoyl)-3-piperidin-1-ylmethyl-3H-benzooxazol-2-one 
• 144220-80-4 6-(2-Fluoro-benzoyl)-3-morpholin-4-ylmethyl-3H-benzooxazol-2-one 
• 144220-76-8 6-(2-Fluoro-benzoyl)-3-(4-methyl-piperidin-1-ylmethyl)-3H-benzooxazol-2-one 
• 144220-74-6 6-(2-Fluoro-benzoyl)-3-(4-phenyl-piperidin-1-ylmethyl)-3H-benzooxazol-2-one 
• 144220-70-2 6-(2-Fluoro-benzoyl)-3-(4-phenyl-piperazin-1-ylmethyl)-3H-benzooxazol-2-one 
• 144220-79-1 3-(4-Benzyl-piperidin-1-ylmethyl)-6-(2-fluoro-benzoyl)-3H-benzooxazol-2-one 
• 144220-75-7 6-(2-Fluoro-benzoyl)-3-(4-hydroxy-4-phenyl-piperidin-1-ylmethyl)-3H-benzooxazol-2-one 
• 144220-73-5 3-(4-Benzyl-piperazin-1-ylmethyl)-6-(2-fluoro-benzoyl)-3H-benzooxazol-2-one 
• 144220-78-0 6-(2-Fluoro-benzoyl)-3-(3-methyl-piperidin-1-ylmethyl)-3H-benzooxazol-2-one 
• 153116-20-2 [6-(2-Fluoro-benzoyl)-2-oxo-benzooxazol-3-yl]-acetic acid ethyl ester 
• 154641-18-6 [6-(2-Fluoro-benzoyl)-2-oxo-benzooxazol-3-yl]-acetonitrile 
• 144220-71-3 6-(2-Fluoro-benzoyl)-3-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-3H-benzooxazol-2-one 

Relevant articles and documents

Some N-Mannich bases of 2-benzoxazolinones and their analgesic activities

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Synthesis and antimicrobial activity of thiazolinomethyl-2(3H)-benzoxazolone derivatives (I)

A number of thiazolinoalkyl-2(3H)-benzoxazolones have been synthesized by using cyano derivatives of 6-acyl-2(3H)-benzoxazolones with cysteamine HCl. Their antibacterial and antifungal activities have been evaluated. The chemical structures have been proved by means of their IR, 1H-NMR and mass spectroscopic data and by elemental analysis. The antimicrobial activity of compounds was investigated by tube dilution and disk techniques using bacteria (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Streptococcus faecalis RSKK 10541) and yeast-like fungi (Candida parapsilosis, C albicans, C pseudotropicalis, C stellatoidea). Inhibitory effects were observed for many compounds against C albicans, eg, compounds 3b and 3c MIC = 25 μg/ml, C pseudotropicalis, eg, compound 3b MIC = 12.5 μg/ml, and P aeruginosa and S faecalis, eg, compound 3c, MIC = 25 μg/ml.

Some new benzoxazolinone derivatives with analgesic and anti-inflammatory activities

Fourteen new 6-acyl-2-benzoxazolinone, ethyl-(6-acyl-2-benzoxazolinone)acetate and (6-acyl-2-benzoxazolinone-3-yl) acetic acid derivatives were synthesized, and their physical properties and UV absorption data were determined. Their chemical structures we