144223-31-4

Basic information

• Product Name: 1-(4-PYRIDYLCARBONYL)BENZOTRIAZOLE
• Synonyms: 1H-Benzotriazole,1-(4-pyridinylcarbonyl)- (9CI); 1-(4-Pyridylcarbonyl)-1H-benzotriazole
• CAS NO: 144223-31-4
• Molecular Formula: C₁₂H₈N₄O
• Molecular Weight: 224.22
• Mol File: 144223-31-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 149-153 °C(lit.)
• Boiling Point: 435.3±37.0 °C(Predicted)
• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• PKA: 1.54±0.10(Predicted)
• CAS DataBase Reference: 1-(4-PYRIDYLCARBONYL)BENZOTRIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-PYRIDYLCARBONYL)BENZOTRIAZOLE(144223-31-4)
• EPA Substance Registry System: 1-(4-PYRIDYLCARBONYL)BENZOTRIAZOLE(144223-31-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36
• WGK Germany: 3
• Hazardous Substances Data: 144223-31-4(Hazardous Substances Data)

Usage

General Description

1-(4-Pyridylcarbonyl)benzotriazole is a chemical compound with the chemical formula C13H9N5O. It is commonly used as a UV absorber or stabilizer in various products, particularly in plastics and coatings, to protect them from the damaging effects of UV radiation. The compound works by absorbing the UV radiation and converting it into harmless heat, thus preventing the degradation and deterioration of the materials it is used in. It is also known to be a potential environmental pollutant and is therefore regulated in some regions. Additionally, it is important to handle and use this chemical with caution as it may pose human health risks if not properly managed.

Upstream product

• 55-22-1 pyridine-4-carboxylic acid 
• 95-14-7 1,2,3-Benzotriazole 
• 14254-57-0 4-(chlorocarbonyl)pyridine 
• 43183-36-4 1-(trimethylsilyl)-1H-benzotriazole 
• 37073-15-7 1-(methanesulfonyl)-1H-1,2,3-benzotriazole 

Downstream Products

• 1453-82-3 isonicotinamide 
• 586-95-8 pyridine-4-methanol 
• 4013-73-4 isonicotinoyl azide 
• 4329-75-3 N,N'-bis(isonicotinoyl)hydrazine 

Relevant articles and documents

Synthesis, computational studies, antimycobacterial and antibacterial properties of pyrazinoic acid-isoniazid hybrid conjugates

Benzotriazole and microwave mediated syntheses led to a new set of hybrid conjugates of pyrazinoic acid with isoniazid via amino acid linkers in excellent yields with retention of chirality. Microbiological screening of the synthesized conjugates revealed an exceptionally high activity against some of the pathogenic bacterial strains at low concentrations. Promising antimycobacterial properties were observed against tuberculous and non-tuberculous mycobacteria. Robust molecular models (2D-QSAR and 3D-pharmacophore) support the observed biological properties. Safety profile of the synthesized conjugates against human normal cell (RPE1) was evaluated by MTT technique.

Preparation of polyfunctional acyl azides

(Chemical Equation Presented) A general synthesis of acyl azides from the corresponding N-acyl benzotriazoles is described. The procedure affords acyl azides in good yields and avoids the use of acid activators and NO+ equivalents typically emp

N-acylbenzotriazoles: Neutral acylating reagents for the preparation of primary, secondary, and tertiary amides

Readily available N-acylbenzotriazoles 2a-q efficiently acylate aqueous ammonia and primary and secondary amines to give primary, secondary, and tertiary amides in good to excellent yields. The wide applicability of the procedure is illustrated by the preparation of (i) α-hydroxyamides from α-hydroxy acids and of (ii) perfluoroalkylated amides.