144243-44-7

Basic information

• Product Name: 1-Pyrrolidinecarboxylic acid, 2-(1-pyrrolidinylcarbonyl)-, 1,1-dimethylethyl ester, (R)-
• CAS NO: 144243-44-7
• Molecular Formula: C14H24N2O3
• Molecular Weight: 268.356
• Mol File: 144243-44-7.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxylic acid, 2-(1-pyrrolidinylcarbonyl)-, 1,1-dimethylethyl ester, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylic acid, 2-(1-pyrrolidinylcarbonyl)-, 1,1-dimethylethyl ester, (R)-(144243-44-7)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylic acid, 2-(1-pyrrolidinylcarbonyl)-, 1,1-dimethylethyl ester, (R)-(144243-44-7)

Safety Data

• Hazardous Substances Data: 144243-44-7(Hazardous Substances Data)

Upstream product

• 1192-63-8 1-pyrrolidinecarbonyl chloride 
• 86953-79-9 tert-butyl pyrrolidine-1-carboxylate 
• 123-75-1 pyrrolidine 
• 883565-15-9 C₁₅H₂₅NO₅ 
• 24424-99-5 di-tert-butyl dicarbonate 
• 344-25-2 D-Prolin 
• 37784-17-1 N-(tert-butoxycarbonyl)-D-proline 
• 1314867-09-8 (S)-tert-butyl 2-(diallylcarbamoyl)pyrrolidine-1-carboxylate 
• 34619-03-9 tert-butyldicarbonate 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 147-85-3 L-proline 

Downstream Products

• 60419-23-0 (R)-(-)-1-(2-pyrrolidinylmethyl)pyrrolidine 
• 144301-82-6 (R)-(+)-1-<2-(3,4-dichlorophenyl)acetyl>-2-(1-pyrrolidinylmethyl)pyrrolidine 
• 144243-13-0 (R)-(+)-1-<2-(3,4-dichlorophenyl)ethyl>-2-(1-pyrrolidinylmethyl)pyrrolidine 
• 485834-26-2 4-((S)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-pyrrolidine-1-carbonyl]-benzoyl}-pyrrolidine-2-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 473797-81-8 isophthalic acid L-proline L-prolyl-pyrrolidine amide 
• 473797-85-2 isophthalic acid (L-proline methyl ester) L-prolyl-pyrrolidine amide 
• 473797-83-0 isophthalic acid mono(L-prolyl-pyrrolidine) amide 
• 473797-79-4 3-[(S)-2-(Pyrrolidine-1-carbonyl)-pyrrolidine-1-carbonyl]-benzoic acid methyl ester 
• 863555-43-5 Boc-L-Phe-L-Pro-N-pyrrolidinyl 

Relevant articles and documents

Double-chiral binaphthalene O-N-N tridentate ligand and preparation method thereof

The invention discloses a bis-chiral binaphthalene O-N-N tridentate ligand and a preparation method thereof. The ligand has the structural formula shown in formula (L). The preparation method comprises the following steps: (1) taking chiral 2 - methyl -2 - methoxy -binaphthalene as a raw material and replacing the reaction with an aromatic ring. As an alternative to the hydroxy protecting group, a brominated derivative (compound IV) is obtained by bromination. (2) Starting from protected chiral proline, a variety of diamine structures are obtained by conversion (Compound B). (3) Compound IV and Compound B are coupled in the presence of a catalyst in the presence of a catalyst to obtain a binaphthalene O-N-N tridentate ligand with bichirality. The ligand preparation method is simple in raw material, and has important significance for asymmetric organic synthesis.

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