14472-80-1Relevant articles and documents
Desymmetrizing Isomerization of Alkene via Thiazolinyl Iminoquinoline Cobalt Catalysis
Liu, Wenbo,Zheng, Yushan,Mao, Yihui,Chen, Jieping,Ren, Xiang,Cheng, Zhaoyang,Lu, Zhan
, p. 1158 - 1163 (2022/02/14)
We report a cobalt-catalyzed desymmetrizing isomerization of exo-cyclic alkenes to generate chiral 1-methylcyclohexene derivatives with good yields and enantioselectivities. A novel chiral thiazolinyl iminoquinoline ligand and its cobalt complex were desi
Base-free oxidation of alcohols enabled by nickel(ii)-catalyzed transfer dehydrogenation
Ye, Danfeng,Liu, Zhiyuan,Sessler, Jonathan L.,Lei, Chuanhu
supporting information, p. 11811 - 11814 (2020/10/13)
An efficient nickel(ii)-catalyzed transfer dehydrogenation oxidation of alcohols is reported that relies on cyclohexanone as the formal oxidant and does not require the use of an external base. The synthetic utility of this protocol is demonstratedviathe facile oxidation of structurally complicated natural products.
Method for synthesizing 4-(4-chlorphenyl)cyclohexanone
-
Paragraph 0028; 0029; 0030, (2017/08/27)
The invention relates to the field of organic synthesis and discloses a method for synthesizing a chemical intermediate 4-(4-chlorphenyl)cyclohexanone. The method includes the steps that firstly, 4-isopropenyl chlorobenzene is mixed with an organic solvent, N-bromo-succinimide is added for reaction for 1-6 h, solid is obtained, washed and dried after the reaction is completed, a compound 2 is obtained, a quenching reaction is carried out, extraction is conducted, an organic phase is obtained, and the compound 2 is obtained; secondly, the compound 2 and diethyl 1,3-acetonedicarboxylate are dissolved in alcohol, sodium alcoholate is added for reaction for 8-20 h, concentration is conducted after the reaction is completed, and a compound 3 is obtained; thirdly, the compound 3 is mixed with alcohol, an alkaline solution is added for a reflux reaction for 3-15 h, the product is adjusted to be alkalescent after the reaction is completed, and an organic phase is obtained, washed and dried after extraction. According to the synthesis method, raw materials are easy to obtain, reaction conditions are mild, selectivity is high, aftertreatment has good operability, the yield is high, production is easy to enlarge, and the method is more environmentally friendly.