1448189-93-2

Basic information

• Product Name: (2S,4R)-methyl 4-hydroxy-1-((S)-2-(1-oxoisoindolin-2-yl)propanoyl)pyrrolidine-2-carboxylate
• Synonyms: (2S,4R)-methyl 4-hydroxy-1-((S)-2-(1-oxoisoindolin-2-yl)propanoyl)pyrrolidine-2-carboxylate
• CAS NO: 1448189-93-2
• Molecular Weight: 332.356
• Mol File: 1448189-93-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S,4R)-methyl 4-hydroxy-1-((S)-2-(1-oxoisoindolin-2-yl)propanoyl)pyrrolidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-methyl 4-hydroxy-1-((S)-2-(1-oxoisoindolin-2-yl)propanoyl)pyrrolidine-2-carboxylate(1448189-93-2)
• EPA Substance Registry System: (2S,4R)-methyl 4-hydroxy-1-((S)-2-(1-oxoisoindolin-2-yl)propanoyl)pyrrolidine-2-carboxylate(1448189-93-2)

Safety Data

• Hazardous Substances Data: 1448189-93-2(Hazardous Substances Data)

Upstream product

• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 180923-78-8 (S)-2-(1-oxoisoindolin-2-yl)propanoic acid 

Relevant articles and documents

Compounds & Methods for the Enhanced Degradation of Targeted Proteins & Other Polypeptides by an E3 Ubiquitin Ligase

The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins that are degraded and/or otherwise inhibited by bifunctional compounds of the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand that binds to the ubiquitin ligase and on the other end a moiety that binds a target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds of the present invention, consistent with the degradation/inhibition of targeted polypeptides.