1448776-35-9

Basic information

• Product Name: N-phenyl-3-difluoromethyl-5-pentafluoroethyl-4-pyrazolecarboxylic acid ethyl ester
• Synonyms: N-phenyl-3-difluoromethyl-5-pentafluoroethyl-4-pyrazolecarboxylic acid ethyl ester
• CAS NO: 1448776-35-9
• Molecular Weight: 384.253
• Mol File: 1448776-35-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-phenyl-3-difluoromethyl-5-pentafluoroethyl-4-pyrazolecarboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-phenyl-3-difluoromethyl-5-pentafluoroethyl-4-pyrazolecarboxylic acid ethyl ester(1448776-35-9)
• EPA Substance Registry System: N-phenyl-3-difluoromethyl-5-pentafluoroethyl-4-pyrazolecarboxylic acid ethyl ester(1448776-35-9)

Safety Data

• Hazardous Substances Data: 1448776-35-9(Hazardous Substances Data)

Upstream product

• 663-35-4 ethylpentafluoropropionylacetate 
• 100-63-0 phenylhydrazine 

Downstream Products

• 1448776-37-1 1-phenyl-3-difluoromethyl-5-pentafluoroethyl-1H-pyrazole-4-carboxylic acid 
• 1571942-57-8 3-(difluoromethyl)-1-phenyl-5-(pentafluoroethyl)-1H-pyrazole 

Relevant articles and documents

METHOD FOR PRODUCING 3,5-BIS(FLUOROALKYL)-PYRAZOL-4-CARBOXYLIC ACID DERIVATIVES AND 3,5-BIS(FLUOROALKYL)-PYRAZOLES

The present invention relates to novel 3,5-bis(fluoroalkyl)pyrazole-4-carboxylic acid derivatives and to a process for preparing 3,5-bis(fluoroalkyl)pyrazole-4-carboxylic acid derivatives and 3,5-bis(fluoroalkyl)pyrazoles.

A new life for an old reagent: Fluoroalkyl amino reagents as efficient tools for the synthesis of diversely fluorinated pyrazoles

Herein we describe the first practical method for the regioselective preparation of 3,5-bis(fluoroalkyl)pyrazoles. Starting from commercially available fluoroacetoacetates and by using (tetrafluoroethyl)dimethylamine as a convenient CF2H transfer reagent, this straightforward one-pot sequence affords highly substituted pyrazoles in good yields and excellent regioselectivity. Furthermore, these carboxylate intermediates were converted into the corresponding pyrazolic acids, which are valuable building blocks for the design of novel bioactive ingredients. Copyright