144951-88-2

Basic information

• Product Name: 1,1,2,2-TETRAFLUORO-2-(1,1,2,2-TETRAFLUOROETHOXY)-ETHANESULFONYL AZIDE
• Synonyms: 1,1,2,2-TETRAFLUORO-2-(1,1,2,2-TETRAFLUOROETHOXY)-ETHANESULFONYL AZIDE
• CAS NO: 144951-88-2
• Molecular Formula: C₄HF₈N₃O₃S
• Molecular Weight: 0
• Mol File: 144951-88-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,1,2,2-TETRAFLUORO-2-(1,1,2,2-TETRAFLUOROETHOXY)-ETHANESULFONYL AZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,2,2-TETRAFLUORO-2-(1,1,2,2-TETRAFLUOROETHOXY)-ETHANESULFONYL AZIDE(144951-88-2)
• EPA Substance Registry System: 1,1,2,2-TETRAFLUORO-2-(1,1,2,2-TETRAFLUOROETHOXY)-ETHANESULFONYL AZIDE(144951-88-2)

Safety Data

• Hazardous Substances Data: 144951-88-2(Hazardous Substances Data)

Usage

Class

Sulfonamide derivative

Use

Reagent in organic synthesis

Application fields

Fluorine chemistry, pharmaceutical research

Function

Introduces fluorine atoms into organic molecules

Property

Enhances chemical and biological properties of molecules

Structure

Unique and reactive

Importance

Valuable tool in developing new materials and pharmaceuticals

Hazard

Potentially explosive substance

Safety

Requires careful handling

Upstream product

• 104729-49-9 5-hydro-3-oxaoctafluoropentanesulfonyl fluoride 

Downstream Products

• 144951-90-6 1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoroethoxy)-ethanesulfonyl amide 
• 144951-91-7 2,2,3,3-Tetramethyl-1-[1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoro-ethoxy)-ethanesulfonyl]-aziridine 
• 144951-89-3 1,1,2,2-Tetrafluoro-2-(1,1,2,2-tetrafluoro-ethoxy)-ethanesulfonic acid cyclohexylamide 
• 144951-93-9 C₂₂H₁₆F₈NO₃PS 
• 623-73-4 diazoacetic acid ethyl ester 
• 845812-06-8 2-(N-methyl-indolinylidene)-(1',1',2',2',4',4',5',5'-octafluoro-3'-oxa-pentyl)-sulfonyl imine 
• 1242102-45-9 N-phenyl-3-(3-oxa-octafluoropentanesulfonamido)pyrrole 
• 1304126-46-2 N,N-diisopropyl-N'-[(1,1,2,2,4,4,5,5-octafluoro-3-oxapentyl)sulfonyl]-2-phenylacetamidine 
• 1304126-50-8 N,N-diisopropyl-2-(4-methoxyphenyl)-N'-[(1,1,2,2,4,4,5,5-octafluoro-3-oxapentyl)sulfonyl]acetamidine 
• 1304126-53-1 N,N-diisopropyl-N'-[(1,1,2,2,4,4,5,5-octafluoro-3-oxapentyl)sulfonyl]-2-(4-tolyl)acetamidine 

Relevant articles and documents

Facile and quantitative synthesis of 1,3-diazaheterocycle-fused 1,2,3-triazole derivatives using fluoroalkanesulfonyl azide as a diazo transfer reagent

A series of 1,3-diazaheterocycle-fused 1,2,3-triazoles were conveniently and quantitatively prepared by 1,3-dipolar cycloaddition of heterocyclic ketene aminals with fluoroalkanesulfonyl azide, followed by elimination of fluoroalkanesulfonyl amide at room

Synthesis and Reactions of Fluoroalkanesulfonyl Azides and N,N-Dichlorofluoroalkanessulfonamides

Thermolysis or photolysis of fluoroalkanesulfonyl azides RFSO2N3 afforded the corresponding nitrene intermediates RFSo2N which reacted readily with alkanes, alkenes, benzene, dimethyl sulfide, dimethyl sulfoxide, pyridine and triphenylphosphine to give insertion or addition products.Similar results were obtained by the reactions of N,N-dichlorofluoroalkanesulfonamides, RFSO2NCl2, with the same reagents in the presence of zinc powder.Treatment of RFSO2NCl2 with alkene in the absence of zinc powder gave only a 1:1 adduct via a free-radical intermediate RfSO2NCl.

Synthesis of fluoroalkanesulfonyl azides and their reactions as fluoroalkanesulfonyl nitrene precursors

Thermolysis or photolysis of the title compounds with cyclohexane, Me2C = CMe2, methyl sulfide and triphenyl phosphine gave the corresponding insertion or addition products via the perfluoroalkanesulfonyl nitrene intermediate.