1453208-02-0

Basic information

• Product Name: 5-[(3,5-dimethoxyphenoxy)methyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine
• Synonyms: 5-[(3,5-dimethoxyphenoxy)methyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine
• CAS NO: 1453208-02-0
• Molecular Weight: 548.685
• Mol File: 1453208-02-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-[(3,5-dimethoxyphenoxy)methyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(3,5-dimethoxyphenoxy)methyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine(1453208-02-0)
• EPA Substance Registry System: 5-[(3,5-dimethoxyphenoxy)methyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine(1453208-02-0)

Safety Data

• Hazardous Substances Data: 1453208-02-0(Hazardous Substances Data)

Upstream product

• 1254058-34-8 3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline 
• 1453211-56-7 2-chloro-5-[(3,5-dimethoxyphenoxy)methyl]pyrimidine 

Relevant articles and documents

Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency

Fibroblast growth factor receptor 3 (FGFR3) is an attractive therapeutic target for the treatment of patients with bladder cancer harboring genetic alterations in FGFR3. We identified pyrimidine derivative 20b, which induced tumor regression following ora