14533-84-7

Basic information

• Product Name: PENTAFLUOROPHENYL TRIFLUOROACETATE
• Synonyms: PFP-O-TFA;PENTAFLUOROPHENYL TRIFLUOROACETATE;PENTAFLUORPHENYL TRIFLUORACETATE;TRIFLUORO ACETIC ACID PENTAFLUORO PHENYL ESTER;TFA-OPFP;Pentafluoropfenyl Trifluoroacetate;perfluorophenyl 2,2,2-trifluoroacetate;Pentafluorophenyl trifluoroacetate,Trifluoroacetic acid pentafluorophenyl ester
• CAS NO: 14533-84-7
• Molecular Formula: C₈F₈O₂
• Molecular Weight: 280.07
• EINECS: 212-235-8
• Mol File: 14533-84-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 4°C(lit.)
• Boiling Point: 122-123 °C(lit.)
• Flash Point: 126 °F
• Appearance: Clear colorless/Oil
• Density: 1.63 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.368(lit.)
• Storage Temp.: Store at RT.
• Water Solubility: Soluble in water at 122.5°Cat760mmHg.
• Sensitive: Moisture Sensitive
• BRN: 2003848
• CAS DataBase Reference: PENTAFLUOROPHENYL TRIFLUOROACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: PENTAFLUOROPHENYL TRIFLUOROACETATE(14533-84-7)
• EPA Substance Registry System: PENTAFLUOROPHENYL TRIFLUOROACETATE(14533-84-7)

Safety Data

• Hazard Codes: Xi,F
• Statements: 10-36/37/38
• Safety Statements: 16-26-36
• RIDADR: UN 3272 3/PG 3
• WGK Germany: 3
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 14533-84-7(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless liquid

Uses

Different sources of media describe the Uses of 14533-84-7 differently. You can refer to the following data:
1. It is used as a pharmaceutical intermediate.
2. Pentafluorophenyl trifluoroacetate can be used:In the esterification of 2′-carboxyrhodamine dye to form pentafluorophenyl ester as a single isomer.As an acylating agent and a coupling agent for the peptide-type coupling of N-substituted glycine oligomers.In the synthesis of pentafluorophenyl thiophene-3-acetate (PFPTA) by reacting with 3-thiopheneacetic acid.

Upstream product

• 354-32-5 trifluoracetyl chloride 
• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 86060-92-6 N-α-Fmoc-L-phenylalanine pentafluorophenyl ester 
• 86061-01-0 tert-butyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-pentafluorophenyl L-aspartate 
• 86060-89-1 N-α-Fmoc-L-isoleucine pentafluorophenyl ester 
• 86069-87-6 N-α-fluorenylmethoxycarbonyl-L-tryptophan pentafluorophenyl ester 
• 86060-93-7 Fmoc-Tyr(tBu)-OPfp 
• 86060-98-2 Fmoc-L-Lys(Boc)-OPfp 
• 115520-21-3 N-α-Fmoc-S-trityl-L-cysteine pentafluorophenyl ester 
• 91741-74-1 2-[({2-[(R)-1-((S)-2-{(R)-2-[((R)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carboxylic acid pentafluorophenyl ester 
• 91741-74-1 2-[({2-[(R)-1-((R)-2-{(S)-2-[((R)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carboxylic acid pentafluorophenyl ester 
• 91741-74-1 2-[({2-[(R)-1-((S)-2-{(S)-2-[((R)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carboxylic acid pentafluorophenyl ester 
• 91741-74-1 2-[({2-[(R)-1-((R)-2-{(R)-2-[((S)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carboxylic acid pentafluorophenyl ester 
• 91741-74-1 2-[({2-[(R)-1-((S)-2-{(R)-2-[((S)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carboxylic acid pentafluorophenyl ester 
• 91741-74-1 2-[({2-[(R)-1-((R)-2-{(S)-2-[((S)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carboxylic acid pentafluorophenyl ester 
• 91741-74-1 2-[({2-[(R)-1-((S)-2-{(S)-2-[((S)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carboxylic acid pentafluorophenyl ester 

Relevant articles and documents

NEW ADJUVANT

The present invention provides a novel adjuvant for polynucleotide vaccines, and in particular the present invention provides immunogenic compositions comprising a polynucleotide encoding an antigen capable of eliciting an immune response and an adjuvant