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Cas Database

14548-42-6

14548-42-6

Identification

Synonyms:2-Propen-1-one, 3-(4-iodophenyl)-1-phenyl-;4-Jodchalcon;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 2 Articles be found

Straightforward synthesis of quinolines from enones and 2-aminobenzyl alcohols using an iridium-catalyzed transfer hydrogenative strategy

Xiong, Biao,Wang, Yingying,Liu, Yuan,Bao, Yandan,Liu, Zhaoguo,Zhang, Yanan,Ling, Yong

supporting information, p. 5707 - 5711 (2018/08/17)

A new protocol for the direct synthesis of quinolines from enones and 2-aminobenzyl alcohols via iridium-catalyzed transfer hydrogenative reactions has been demonstrated. This method employs easily available [IrCp?Cl2]2/t-BuOK as the efficient catalyst system, proceeding with the merits of high step- and atom efficiency, mild reaction conditions and operational simplicity. The experimental studies suggest that the reactions start with transfer hydrogenation, followed by the Friedl?nder reaction to give the final products.

Process route upstream and downstream products

Process route

acetophenone
98-86-2

acetophenone

p-(iodophenyl)carboxaldehyde
15164-44-0

p-(iodophenyl)carboxaldehyde

<4-Iodbenzyliden>acetophenon
14548-42-6

<4-Iodbenzyliden>acetophenon

Conditions
Conditions Yield
With potassium hydroxide; In methanol; at 50 ℃;
90%
With potassium hydroxide; In ethanol; at 0 - 20 ℃;
63%
<4-Iodbenzyliden>acetophenon
14548-42-6

<4-Iodbenzyliden>acetophenon

Conditions
Conditions Yield
Acetophenon, 4-Iod-benzaldehyd;
Acetophenon, p-Iodbenzaldehyd, ethanol. NaOH;
2-Aminobenzyl alcohol
5344-90-1

2-Aminobenzyl alcohol

<4-Iodbenzyliden>acetophenon
14548-42-6

<4-Iodbenzyliden>acetophenon

3-(4-iodobenzyl)-2-phenylquinoline

3-(4-iodobenzyl)-2-phenylquinoline

Conditions
Conditions Yield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; potassium tert-butylate; In tert-Amyl alcohol; at 20 ℃; for 12h; Inert atmosphere; Schlenk technique;
78%
nitromethane
75-52-5

nitromethane

<4-Iodbenzyliden>acetophenon
14548-42-6

<4-Iodbenzyliden>acetophenon

3-(4-iodophenyl)-4-nitro-1-phenylbutan-1-one
1239588-89-6

3-(4-iodophenyl)-4-nitro-1-phenylbutan-1-one

Conditions
Conditions Yield
With diethylamine; In methanol; for 48h; Reflux;
72%
<4-Iodbenzyliden>acetophenon
14548-42-6

<4-Iodbenzyliden>acetophenon

C<sub>32</sub>H<sub>21</sub>I<sub>2</sub>N<sub>3</sub>
1256705-54-0

C32H21I2N3

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: diethylamine / methanol / 48 h / Reflux
2: ammonium acetate / butan-1-ol / 56 h / Inert atmosphere; Reflux
With ammonium acetate; diethylamine; In methanol; butan-1-ol;
<4-Iodbenzyliden>acetophenon
14548-42-6

<4-Iodbenzyliden>acetophenon

phenylhydrazine
100-63-0

phenylhydrazine

5-(4-iodo-phenyl)-1,3-diphenyl-4,5-dihydro-1<i>H</i>-pyrazole
3600-52-0

5-(4-iodo-phenyl)-1,3-diphenyl-4,5-dihydro-1H-pyrazole

Conditions
Conditions Yield
With ethanol;
<4-Iodbenzyliden>acetophenon
14548-42-6

<4-Iodbenzyliden>acetophenon

3-(4-iodophenyl)-1-phenylpropan-1-ol
62056-17-1

3-(4-iodophenyl)-1-phenylpropan-1-ol

Conditions
Conditions Yield
With lithium aluminium tetrahydride;

Global suppliers and manufacturers

Global( 1) Suppliers
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  • PRIME MOLECULAR CO.,LIMITED
  • Business Type:Trading Company
  • Contact Tel:0852-0755-61104662
  • Emails:sales@prime-molecular.com
  • Main Products:1
  • Country:China (Mainland)
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