145937-21-9Relevant articles and documents
6-Gingesulfonic acid, a new anti-ulcer principle, and gingerglycolipids A, B and C, three new monoacyldigalactosylglycerols from Zingiberis rhizoma originating in Taiwan
Yoshikawa,Hatakeyama,Taniguchi,Matuda,Yamahara
, p. 2239 - 2241 (1992)
By monitoring the effects of HCl/ethanol-induced gastric lesions in rats, a new anti-ulcer principle named 6-gingesulfonic acid was isolated from Zingiberis Rhizoma, the dried rizhome of Zingiber officinale Roscoe (cultivated and processed in Taiwan) toge
First enantioselective synthesis of gingesulfonic acids and unequivocal determination of their absolute stereochemistry
Adamo, Mauro F. A.,Bencivenni, Grazia,Gillick-Healy, Malachi W.,Kelly, Brian G.,Moccia, Maria,Ravelli, Andrea
supporting information, p. 1091 - 1094 (2020/02/22)
Herein we report the first organocatalysed enantioselective synthesis of gingesulfonic acids and shogasulfonic acids via a mild and convenient aminothiourea-catalysed conjugate addition of bisulfite to the olefin moiety of α,β-unsaturated carbonyls - a technology previously reported by us. A series of optically active naturally occurring sulfonic acids are prepared in their natural and unnatural configurations, and their absolute configurations are unequivocally confirmed by single crystal X-ray diffractometry.