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14605-22-2

14605-22-2

Identification

Synonyms:tauroursodeoxycholate Sodium;Taurine,N-(3a,7b-dihydroxy-5b-cholan-24-oyl)- (8CI);Tauroursodeoxycholic acid (6CI,7CI);3a,7b-Dihydroxy-5b-cholanoyltaurine;UR 906;Ursodeoxycholyltaurine;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:AK Scientific
  • Product Description:Tauroursodeoxycholicaciddihydrate
  • Packaging:25g
  • Price:$ 241
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:TAUROURSODEOXYCHOLIC ACID 95.00%
  • Packaging:5MG
  • Price:$ 495.01
  • Delivery:In stock
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  • Manufacture/Brand:Arctom
  • Product Description:Tauroursodeoxycholicacid ≥98%
  • Packaging:20mg
  • Price:$ 40
  • Delivery:In stock
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  • Manufacture/Brand:AvaChem
  • Product Description:Tauroursodeoxycholic acid
  • Packaging:20mg
  • Price:$ 39
  • Delivery:In stock
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  • Manufacture/Brand:AvaChem
  • Product Description:Tauroursodeoxycholic acid
  • Packaging:1g
  • Price:$ 339
  • Delivery:In stock
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  • Manufacture/Brand:Biorbyt Ltd
  • Product Description:Tauroursodeoxycholic acid >98%,Standard References Grade
  • Packaging:20 mg
  • Price:$ 569.5
  • Delivery:In stock
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  • Manufacture/Brand:Biorbyt Ltd
  • Product Description:TUDCA >98%
  • Packaging:1 g
  • Price:$ 217.6
  • Delivery:In stock
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  • Manufacture/Brand:Biorbyt Ltd
  • Product Description:TUDCA >98%
  • Packaging:500 mg
  • Price:$ 146.2
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:Tauroursodeoxycholic acid
  • Packaging:25 g
  • Price:$ 165
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:Tauroursodeoxycholic acid
  • Packaging:10 g
  • Price:$ 80
  • Delivery:In stock
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Relevant articles and documentsAll total 7 Articles be found

Method for synthesizing tauroursodeoxycholic acid under promotion of trichloroisocyanuric acid

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Paragraph 0029-0031; 0034-0041, (2021/04/03)

The invention relates to the technical field of medicine synthesis, in particular to a method for synthesizing tauroursodeoxycholic acid under the promotion of trichloroisocyanuric acid. The method sequentially comprises the following steps: an intermediate product synthesis step: reacting taurine under the action of trichloroisocyanuric acid to obtain a system I; synthesizing tauroursodeoxycholicacid, namely adding tauroursodeoxycholic acid and alkali into the system I, and reacting to obtain a system II; the synthetic method has the advantages of economy and environmental protection, is simple in operation process, is suitable for industrial expansion, and can be applied to production practice of tauroursodeoxycholic acid.

niu Huangxiong method for the preparation of sodium deoxycholate

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Paragraph 0033-0041, (2017/05/06)

The invention provides a method for preparing sodium tauroursodeoxycholate. The method comprises (1) using ursodesoxycholic acid as raw materials and getting a mixed anhydride solution through acetylation and chloride reactions; (2) dissolving taurine into a sodium carbonate solution to get a taurine sodium carbonate solution which is then added in drops into the mixed anhydride solution of step (1) with stirring, and then filtering precipitate to get a filtrate; (3) adjusting pH of the filtrate of step (2) to 6 to 7, concentrating and drying to get crude dried products of tauro-ursodesoxycholic acid; and (4) desalting purifying and re-crystallizing the concentrated dried products of step (3) to get the sodium tauroursodeoxycholate. The method is low in cost and short in technology route, with a yield up to 78%, and is suitable for industrial scale production.

Process for the preparation of tauroursodesoxycholic acid

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Page/Page column 4, (2008/12/04)

The present invention relates to a novel method for preparing tauroursodeoxycholic acid which comprises a step of selective precipitation of the impurities present in the suspension obtained from the reaction of an aqueous solution of sodium taurinate with an acetonic solution of a mixed anhydride of ursodeoxycholic acid with an alkyl chloroformate.

Process route upstream and downstream products

Process route

Conditions
Conditions Yield
With sodium hydroxide; In methanol; water; at 60 ℃; for 10h; Temperature; Solvent;
85%
taurine potassium 18-crown-6 complex

taurine potassium 18-crown-6 complex

4-nitrophenyl ursodeoxycholate
91613-11-5

4-nitrophenyl ursodeoxycholate

Conditions
Conditions Yield
With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 5h;
84.7%
Conditions
Conditions Yield
In dichloromethane; at 20 ℃; for 5h; Concentration; Temperature;
86.8%
Conditions
Conditions Yield
In dichloromethane; at 20 ℃; for 5h;
85.2%
Conditions
Conditions Yield
Tau; C27H44O6; With sodium carbonate; In water; at 20 - 30 ℃;
With hydrogenchloride; In water; pH=6 - 7;
Conditions
Conditions Yield
With hydrogenchloride; In water; acetone; for 1h;
Conditions
Conditions Yield
With ethanol; sodium hydroxide; at 78 ℃; Reagent/catalyst; Temperature;
0.82 g
Conditions
Conditions Yield
With 4-methyl-morpholine; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In ethanol; for 0.05h; Irradiation;
67%
Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: dicyclohexyl-carbodiimide / dichloromethane / 2 h / 20 - 45 °C
2: dicyclohexyl-carbodiimide / dichloromethane / 5 h / 20 °C
With dicyclohexyl-carbodiimide; In dichloromethane;
Multi-step reaction with 2 steps
1: dicyclohexyl-carbodiimide / dichloromethane / 2 h / 5 - 20 °C
2: dichloromethane / 5 h / 20 °C
With dicyclohexyl-carbodiimide; In dichloromethane;

Global suppliers and manufacturers

Global( 215) Suppliers
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  • Hubei Vanz Pharm Co.,Ltd
  • Business Type:Manufacturers
  • Contact Tel:86-27-84492310
  • Emails:sales08@vanzpharm.com
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  • Country:China (Mainland)
  • Wuhan Wonda Pharm Limited
  • Business Type:Lab/Research institutions
  • Contact Tel:027-84306245
  • Emails:wonda-chem@outlook.com
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  • Antimex Chemical Limied
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  • Contact Tel:0086-21-50563169
  • Emails:anthony@antimex.com
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  • Simagchem Corporation
  • Business Type:Manufacturers
  • Contact Tel:+86-592-2680277
  • Emails:sale@simagchem.com
  • Main Products:110
  • Country:China (Mainland)
  • Hangzhou Dingyan Chem Co., Ltd
  • Business Type:Manufacturers
  • Contact Tel:86-571-86465881,86-571-87157530,86-571-88025800
  • Emails:sales@dingyanchem.com
  • Main Products:95
  • Country:China (Mainland)
  • Kono Chem Co.,Ltd
  • Business Type:Other
  • Contact Tel:86-29-86107037-8015
  • Emails:info@konochemical.com
  • Main Products:82
  • Country:China (Mainland)
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