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Method for synthesizing tauroursodeoxycholic acid under promotion of trichloroisocyanuric acid
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Paragraph 0029-0031; 0034-0041, (2021/04/03)
The invention relates to the technical field of medicine synthesis, in particular to a method for synthesizing tauroursodeoxycholic acid under the promotion of trichloroisocyanuric acid. The method sequentially comprises the following steps: an intermediate product synthesis step: reacting taurine under the action of trichloroisocyanuric acid to obtain a system I; synthesizing tauroursodeoxycholicacid, namely adding tauroursodeoxycholic acid and alkali into the system I, and reacting to obtain a system II; the synthetic method has the advantages of economy and environmental protection, is simple in operation process, is suitable for industrial expansion, and can be applied to production practice of tauroursodeoxycholic acid.
niu Huangxiong method for the preparation of sodium deoxycholate
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Paragraph 0033-0041, (2017/05/06)
The invention provides a method for preparing sodium tauroursodeoxycholate. The method comprises (1) using ursodesoxycholic acid as raw materials and getting a mixed anhydride solution through acetylation and chloride reactions; (2) dissolving taurine into a sodium carbonate solution to get a taurine sodium carbonate solution which is then added in drops into the mixed anhydride solution of step (1) with stirring, and then filtering precipitate to get a filtrate; (3) adjusting pH of the filtrate of step (2) to 6 to 7, concentrating and drying to get crude dried products of tauro-ursodesoxycholic acid; and (4) desalting purifying and re-crystallizing the concentrated dried products of step (3) to get the sodium tauroursodeoxycholate. The method is low in cost and short in technology route, with a yield up to 78%, and is suitable for industrial scale production.
Process for the preparation of tauroursodesoxycholic acid
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Page/Page column 4, (2008/12/04)
The present invention relates to a novel method for preparing tauroursodeoxycholic acid which comprises a step of selective precipitation of the impurities present in the suspension obtained from the reaction of an aqueous solution of sodium taurinate with an acetonic solution of a mixed anhydride of ursodeoxycholic acid with an alkyl chloroformate.