146137-76-0

Basic information

• Product Name: 2-Fluoro-5-iodobenzaldehyde
• Synonyms: 2-FLUORO-5-IODOBENZALDEHYDE 97;2-Fluoro-5-iodobenzaldehyde;2-Fluoro-5-iodobenzaldehyde 97%;Benzaldehyde,2-fluoro-5-iodo-
• CAS NO: 146137-76-0
• Molecular Formula: C₇H₄FIO
• Molecular Weight: 250.01
• Product Categories: Multisubstituted Benzene;Adehydes, Acetals & Ketones;Fluorine Compounds;Iodine Compounds;Aldehydes;C7;Carbonyl Compounds
• Mol File: 146137-76-0.mol

Chemical Properties

• Melting Point: 45-48 °C(lit.)
• Boiling Point: 261.9°Cat760mmHg
• Flash Point: >230 °F
• Appearance: White to yellow/Crystals and Chunks
• Density: 1.962g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive: Air & Light Sensitive
• CAS DataBase Reference: 2-Fluoro-5-iodobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-5-iodobenzaldehyde(146137-76-0)
• EPA Substance Registry System: 2-Fluoro-5-iodobenzaldehyde(146137-76-0)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 146137-76-0(Hazardous Substances Data)

Usage

Chemical Properties

White to yellow crystals and chunks

Upstream product

• 352-34-1 4-fluoro-1-iodobenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 109-72-8 n-butyllithium 
• 108-18-9 diisopropylamine 

Downstream Products

• 146137-90-8 methyl 5-iodobenzo[b]thiophene-2-carboxylate 
• 1075176-96-3 (Z)-2-(2-fluoro-5-iodostyryl)-1,3-dimethylbenzene 
• 1075176-95-2 (E)-2-(2-fluoro-5-iodostyryl)-1,3-dimethylbenzene 
• 1025762-98-4 1-(4-fluorophenyl)-5-iodo-1H-indazole 
• 1034148-00-9 2,2,2-trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-phenylpropan-2-yl)acetamide 
• 1034148-16-7 N-((1R,2S)-1-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-1-(6-methoxypyridin-3-yl)propan-2-yl)cyclopropanecarboxamide 
• 1028527-85-6 (1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(4-(methylthio)phenyl)propan-2-amine 
• 1034148-08-7 2-(((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(4-(methylthio)phenyl)propan-2-yl)amino)-2-oxoethyl acetate 

Relevant articles and documents

A benzo[b]thiophene-based selective type 4 S1P receptor agonist

S1P receptors (S1PR1-5) are a group of GPCRs activated by a high affinity binding with S1P that have important roles in the regulation of the immune system. A potent S1PR agonist FTY720 is an immunomodulator used to treat multiple sclerosis and several ‘second generation’ drugs are under clinical development. Subtype-selective agonists have been reported for each S1PR isotype, some of which are used as pharmacological tools for functional studies. Here we report the discovery and initial characterization of compound 5c, a benzo[b]thiophene amino carboxylate which exhibits potent and selective agonist activity for S1PR4. Compound 5c has an EC50= 200 nM as an agonist in GTPγ35S binding assay for S1PR4 and exhibits no activity against S1PR1,2,3,5. We confirmed its potent activity and decent S1PR subtype selectivity using biochemical and cellular assays.

Compounds and method for inhibiting MRP1

The present invention relates to a compound of formula (I), which is useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.

Fluorine as an ortho-directing group in aromatic metalation: A two step preparation of substituted benzo[b] thiophene-2-carboxylates

A simple 2-step synthesis of B-ring substituted benzo[b]thiophene-2-carboxylates from aryl fluorides has been developed. The route involves a selective lithiation ortho to fluorine, followed by formylation, and subsequently, displacement of fluorine with