14617-06-2

Basic information

• Product Name: 4-(2,4-dimethoxyphenyl)-4-oxo-butanoic acid
• Synonyms: 4-(2,4-dimethoxyphenyl)-4-oxo-butanoic acid
• CAS NO: 14617-06-2
• Molecular Formula: C₁₂H₁₄O₅
• Molecular Weight: 238.24
• Mol File: 14617-06-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 148 °C
• Boiling Point: 452.3°Cat760mmHg
• Flash Point: 176.1°C
• Appearance: /
• Density: 1.211g/cm³
• Vapor Pressure: 5.7E-09mmHg at 25°C
• Refractive Index: 1.527
• PKA: 4.46±0.17(Predicted)
• CAS DataBase Reference: 4-(2,4-dimethoxyphenyl)-4-oxo-butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,4-dimethoxyphenyl)-4-oxo-butanoic acid(14617-06-2)
• EPA Substance Registry System: 4-(2,4-dimethoxyphenyl)-4-oxo-butanoic acid(14617-06-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 14617-06-2(Hazardous Substances Data)

Usage

General Description

4-(2,4-dimethoxyphenyl)-4-oxo-butanoic acid is a chemical compound with the molecular formula C12H14O5. It is a derivative of butanoic acid, containing a 4-oxo group and a 2,4-dimethoxyphenyl group. 4-(2,4-dimethoxyphenyl)-4-oxo-butanoic acid is commonly used in organic synthesis and pharmaceutical research due to its unique chemical structure and potential biological activities. It may have potential applications in the development of new drugs or as a building block for the synthesis of other organic compounds. Additionally, it is important to handle this compound with care and follow proper safety protocols when working with it in a laboratory setting.

InChI:InChI=1/C12H14O5/c1-16-8-3-4-9(11(7-8)17-2)10(13)5-6-12(14)15/h3-4,7H,5-6H2,1-2H3,(H,14,15)

Upstream product

• 108-30-5 succinic acid anhydride 
• 151-10-0 1,3-Dimethoxybenzene 
• 108-46-3 recorcinol 
• 292638-85-8 acrylic acid methyl ester 
• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 
• 42907-96-0 β-(2-hydroxy-4-methoxybenzoyl)propionic acid methyl ester 
• 74-88-4 methyl iodide 
• 14794-31-1 ethyl 3-(chloroformyl)propionate 
• 13335-54-1 4-(2,4-dihydroxy-phenyl)-4-oxo-butyric acid 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 14563-41-8 4-(2,4-dimethoxy-phenyl)-4-oxo-butyric acid methyl ester 
• 1121702-77-9 C₂₂H₂₆N₂O₆ 
• 1121702-75-7 C₂₉H₃₂N₂O₆ 
• 857791-69-6 4-(5-bromo-2,4-dimethoxy-phenyl)-3-hydroxy-4-oxo-butyric acid 
• 856075-91-7 4-(5-bromo-2,4-dimethoxy-phenyl)-2-methoxy-4-oxo-butyric acid methyl ester 
• 69163-57-1 4-(5-bromo-2,4-dimethoxy-phenyl)-4-oxo-butyric acid methyl ester 
• 156868-43-8 2,4-dimethoxybenzenebutanoic acid methyl ester 
• 156868-45-0 2,4-methoxy-α,α-dimethylbenzenebutanol 
• 856075-94-0 3-bromo-4-(5-bromo-2,4-dimethoxy-phenyl)-4-oxo-butyric acid 

Relevant articles and documents

TMSCl-Catalyzed Electrophilic Thiocyano Oxyfunctionalization of Alkenes Using N-Thiocyano-dibenzenesulfonimide

Numerous electrophilic thiocyano oxyfunctionalization reactions of alkenes have been achieved using N-thiocyano-dibenzenesulfonimide, which is a new electrophilic thiocyanation reagent and could be easily prepared in two steps from dibenzenesulfonimide. T

Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors

The involvement of μ-calpain in neurological disorders, such as stroke and Alzheimer's disease has attracted considerable interest in the use of calpain inhibitors as therapeutic agents. 4-Aryl-4-oxobutanoic acid amide derivatives 4 were designed as acyclic variants of μ-calpain inhibitory chromone and quinolinone derivatives. Of the compounds synthesized, 4c-2, which possesses a 2-methoxymethoxy group at the phenyl ring and a primary amide at the warhead region most potently inhibited μ-calpain (IC50 = 0.34 μM). Our findings suggest that the 4-aryl-4-oxobutanoic acid amide derivatives should be considered as a new family of μ-calpain inhibitors.

Process for the production of cyclic sulfonium salts

A process for the production of a 5-7 membered ring cyclic sulfonium salt compound, including a 5-7 membered ring cyclic sulfonium salt compound having a non-nucleophilic anion, is described. Members of the latter group are potentially useful as initiators for cationic polymerizations. The process comprises reacting a 1.4-, 1.5-, or 1.6-diol compound or a 5-7 membered ring cyclic ether compound with a mercapto compound and a strong protonic acid yielding the cyclic sulfonium salt compound. Some compounds described are also novel compounds per se.