146564-06-9

Basic information

• Product Name: 1H-Indole, 4-methyl-1-(phenylsulfonyl)-
• CAS NO: 146564-06-9
• Molecular Formula: C15H13NO2S
• Molecular Weight: 271.34
• Mol File: 146564-06-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 4-methyl-1-(phenylsulfonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 4-methyl-1-(phenylsulfonyl)-(146564-06-9)
• EPA Substance Registry System: 1H-Indole, 4-methyl-1-(phenylsulfonyl)-(146564-06-9)

Safety Data

• Hazardous Substances Data: 146564-06-9(Hazardous Substances Data)

Upstream product

• 16096-32-5 4-methyl-1H-indole 
• 98-09-9 benzenesulfonyl chloride 
• 157396-13-9 ethyl 4-(4-chlorophenylthio)-4-(1-phenylsulfonyl-1H-pyrrol-2-yl)butanoate 
• 157396-14-0 4-(4-chlorophenylthio)-4-(1-phenylsulfonyl-1H-pyrrol-2-yl)butanoyl chloride 
• 16851-82-4 N-phenylsulfonylpyrrole 
• 157396-11-7 7-(4-chlorophenylthio)-6,7-dihydro-1-(phenylsulfonyl)-1H-indol-4(5H)-one 
• 146564-05-8 1-Benzenesulfonyl-7-(4-chloro-phenylsulfanyl)-4-methyl-4,5,6,7-tetrahydro-1H-indol-4-ol 

Downstream Products

• 1542708-19-9 N-benzyl-2-(2,4-dimethyl-1H-indol-1-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine 
• 10299-61-3 2,4-dimethyl-1H-indole 
• 856111-26-7 1-benzenesulfonyl-4-phenylsulfanylmethyl-1H-indole 
• 896138-24-2 (5-benzyloxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)methanone 
• 146073-06-5 1-(benzenesulphonyl)-1H-indole-4-carboxaldehyde 
• 896137-96-5 (5-benzyloxy-1-phenylsulfonyl-1H-indol-2-yl)-(4-methyl-1-phenylsulfonyl-1H-indol-2-yl)methanone 
• 896137-84-1 (5-methoxy-1-phenylsulfonyl-1H-indol-2-yl)-(4-methyl-1-phenylsulfonyl-1H-indol-2-yl)methanone 
• 896137-95-4 (5-fluoro-1-phenylsulfonyl-1H-indol-2-yl)-(4-methyl-1-phenylsulfonyl-1H-indol-2-yl)methanone 
• 177210-25-2 1-phenylsulfonyl-4-(bromomethyl)indole 
• 1262322-64-4 C₁₇H₁₅NO₃S 

Relevant articles and documents

Cu-Catalyzed Oxidation of C2 and C3 Alkyl-Substituted Indole via Acyl Nitroso Reagents

The selective oxidation of C2-alkyl-substituted indoles to 3-oxindole and the selective C-H oxygenation or amination of C2,C3-dialkyl-substituted indoles at C2 are reported under mild conditions. The position of the alkyl substitution on the indole directs the reaction to different pathways under similar conditions.

Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083)

The AAA-ATPase p97 plays vital roles in mechanisms of protein homeostasis, including ubiquitin-proteasome system (UPS) mediated protein degradation, endoplasmic reticulum-associated degradation (ERAD), and autophagy. Herein we describe our lead optimization efforts focused on in vitro potency, ADME, and pharmaceutical properties that led to the discovery of a potent, ATP-competitive, D2-selective, and orally bioavailable p97 inhibitor 71, CB-5083. Treatment of tumor cells with 71 leads to significant accumulation of markers associated with inhibition of UPS and ERAD functions, which induces irresolvable proteotoxic stress and cell death. In tumor bearing mice, oral administration of 71 causes rapid accumulation of markers of the unfolded protein response (UPR) and subsequently induces apoptosis leading to sustained antitumor activity in in vivo xenograft models of both solid and hematological tumors. 71 has been taken into phase 1 clinical trials in patients with multiple myeloma and solid tumors.

Substituted 4-aminocyclohexane derivatives

Substituted 4-aminocyclohexane derivatives having the formula I: [image] wherein R1-R4 are as described herein, methods for their preparation, medicinal products and pharmaceutical compositions containing these compounds and the use of substituted 4-amino