146667-89-2

Basic information

• Product Name: 4-chloro-2-nitro-1-vinylbenzene
• Synonyms: 4-chloro-2-nitro-1-vinylbenzene
• CAS NO: 146667-89-2
• Molecular Weight: 183.594
• Mol File: 146667-89-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-chloro-2-nitro-1-vinylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2-nitro-1-vinylbenzene(146667-89-2)
• EPA Substance Registry System: 4-chloro-2-nitro-1-vinylbenzene(146667-89-2)

Safety Data

• Hazardous Substances Data: 146667-89-2(Hazardous Substances Data)

Upstream product

• 41513-04-6 2-chloro-5-bromonitrobenzene 
• 74-85-1 ethene 

Downstream Products

• 1374134-82-3 methyl 4'-ethyl-2-methyl-3'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)biphenyl-4-carboxylate 
• 17422-33-2 6-chloroindole 
• 146667-96-1 2,2-dimethoxy-1-(4-chloro-2-nitrophenyl)ethane 

Relevant articles and documents

Pd-tBuONO Cocatalyzed Aerobic Indole Synthesis

A Pd-tBuONO co-catalyzed scalable and practical synthesis of indoles with molecular oxygen as terminal oxidant is developed. Either terminal or internal 2-vinylanilines could be smoothly converted to desired indoles under one general condition. This method has been evaluated in the large scale synthesis of indomethacin and a potential anti-breast cancer drug candidate 1. (Figure presented.).

Palladium-Catalyzed Synthesis of Indoles from 2-Nitrostyrenes

In the presence of palladium salts, oxidation of 2-nitrostyrenes 1 with nitrous acid alkyl esters 2 resulted in the formation of 2-nitrophenylacetaldehyde dialkyl acetals 3.Reductive cyclization of the acetals 3 with iron powder in acetic acid afforded indoles 5 in good yield.