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146684-74-4

Z-D-TIC-OH, also known as 5-(3,4-dihydroxybenzoyl)-1,2,3,3a,8,8a-hexahydro-3,3,8,8-tetramethyl-1,3a,4,7-diepoxyazuleno[4,5-b]furan-5-ol, is a synthetic derivative of the natural product podophyllotoxin. It is an antineoplastic agent that inhibits the growth of cancer cells by interfering with their ability to replicate DNA. Z-D-TIC-OH exerts its effects by binding to tubulin, a component of the cytoskeleton that is essential for cell division. This disrupts the formation of the mitotic spindle, ultimately leading to cell death.

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  • 146684-74-4 Structure

  • Basic information

    1. Product Name: Z-D-TIC-OH
    2. Synonyms: (R)-(-)-2-(BENZYLOXYCARBONYL)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID;N-ALPHA-CARBOBENZOXY-D-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID;Z-D-TIC-OH;Z-D-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID;Z-D-[3R]-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID;Z-[3R]-1,2,3,4-TETRAHYDROISOQUINOLENE-3-CARBOXYLIC ACID;(3R)-2-Carbobenzoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;Cbz-D-Tic-OH
    3. CAS NO:146684-74-4
    4. Molecular Formula: C18H17NO4
    5. Molecular Weight: 311.33
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 146684-74-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 522.5°Cat760mmHg
    3. Flash Point: 269.8°C
    4. Appearance: /
    5. Density: 1.308g/cm3
    6. Vapor Pressure: 9.56E-12mmHg at 25°C
    7. Refractive Index: 1.619
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. CAS DataBase Reference: Z-D-TIC-OH(CAS DataBase Reference)
    11. NIST Chemistry Reference: Z-D-TIC-OH(146684-74-4)
    12. EPA Substance Registry System: Z-D-TIC-OH(146684-74-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 146684-74-4(Hazardous Substances Data)

146684-74-4 Usage

Uses

Used in Oncology:
Z-D-TIC-OH is used as an antineoplastic agent for its ability to inhibit the growth of cancer cells by binding to tubulin and disrupting the formation of the mitotic spindle, leading to cell death. It has shown potential as a treatment for various types of cancer, including melanoma and leukemia.
Used in Combination Therapies:
Z-D-TIC-OH is being studied for its potential use in combination therapies to enhance its efficacy in treating cancer. By combining it with other treatments, researchers aim to improve the overall effectiveness of cancer therapies and potentially overcome drug resistance.

Check Digit Verification of cas no

The CAS Registry Mumber 146684-74-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,6,8 and 4 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 146684-74:
(8*1)+(7*4)+(6*6)+(5*6)+(4*8)+(3*4)+(2*7)+(1*4)=164
164 % 10 = 4
So 146684-74-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H17NO4/c20-17(21)16-10-14-8-4-5-9-15(14)11-19(16)18(22)23-12-13-6-2-1-3-7-13/h1-9,16H,10-12H2,(H,20,21)/t16-/m1/s1

146684-74-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (3R)-2-phenylmethoxycarbonyl-3,4-dihydro-1H-isoquinoline-3-carboxylic acid

1.2 Other means of identification

Product number -
Other names Z-D-Tic-OH

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:146684-74-4 SDS

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