146998-27-8

Basic information

• Product Name: N(ALPHA)-FMOC-N(EPSILON)-DABCYL-L-LYSINE
• Synonyms: nα-fmoc-nε-dabcyl-l-lysine;Fmoc-Lys(Dabcyl)-OH, Nε-4-[4-(Dimethylamino)phenylazo)benzoyl]-Nα-Fmoc-L-lysine;(S)-2-(((9H-fluoren-9-yl)methyl9H-fluoren-9-yl)methoxy)carbonylamino)-6-(4-((4-(dimethylamino)phenyl)diazenyl)benzamido)hexanoic acid;Fmoc-Ne-dimethylaminophenyldiazobenzoyl-L-lysine;N6-[4-[[4-(Dimethylamino)phenyl]azo]benzoyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine;N^e-4-[4-(DiMethylaMino)phenylazo]benzoyl-N^a-FMoc-L-lysine, 95%;Nα-Fmoc-Nε-Dabcyl-L-lysine technical;Nα-FMoc-Nε-Dabcyl-L-lysine technical
• CAS NO: 146998-27-8
• Molecular Formula: C36H37N5O5
• Molecular Weight: 619.71
• Product Categories: amino acids
• Mol File: 146998-27-8.mol

Chemical Properties

• Appearance: Red/Crystalline Powder
• Density: 1.26
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N(ALPHA)-FMOC-N(EPSILON)-DABCYL-L-LYSINE(CAS DataBase Reference)
• NIST Chemistry Reference: N(ALPHA)-FMOC-N(EPSILON)-DABCYL-L-LYSINE(146998-27-8)
• EPA Substance Registry System: N(ALPHA)-FMOC-N(EPSILON)-DABCYL-L-LYSINE(146998-27-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 146998-27-8(Hazardous Substances Data)

Usage

Uses

1. Used in Peptide Synthesis:
N(ALPHA)-FMOC-N(EPSILON)-DABCYL-L-LYSINE is used as a building block for peptide synthesis, specifically for in-sequence Lys labeling. This application is crucial for the development of novel peptides and proteins with specific functionalities and properties.
2. Used in Pharmaceutical Industry:
In the pharmaceutical industry, N(ALPHA)-FMOC-N(EPSILON)-DABCYL-L-LYSINE is used as a key component in the development of new drugs and therapeutic agents. Its ability to label peptides and proteins allows for the creation of targeted drug delivery systems and the enhancement of drug efficacy.
3. Used in Research and Development:
N(ALPHA)-FMOC-N(EPSILON)-DABCYL-L-LYSINE is employed as a research tool in various scientific fields, including biochemistry, molecular biology, and biotechnology. It aids in the study of protein structure, function, and interactions, contributing to the advancement of scientific knowledge and the development of innovative solutions.
4. Used in Diagnostics:
In the diagnostics industry, N(ALPHA)-FMOC-N(EPSILON)-DABCYL-L-LYSINE is utilized for the development of diagnostic tools and assays. Its ability to label peptides and proteins enables the creation of highly specific and sensitive diagnostic tests for various diseases and conditions.
5. Used in Chemical Synthesis:
N(ALPHA)-FMOC-N(EPSILON)-DABCYL-L-LYSINE is also used in chemical synthesis for the production of various compounds and materials. Its unique chemical properties make it a valuable reagent in the synthesis of complex organic molecules and polymers.

Upstream product

• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 185503-99-5 N^α-dabcyllysine 
• 146998-31-4 4-((4-(dimethylamino)phenyl)azo)benzoic acid succinimidyl ester 
• 139262-23-0 9-fluorenylmethoxycarbonyl-L-alanine hydrochloride 

Relevant articles and documents

ENZYME DETECTION COMPOUND AND MANUFACTURING METHOD OF THE COMPOUND

PROBLEM TO BE SOLVED: To obtain a noel compound for detecting enzyme and a detection method of enzyme using the same and a compound having following structure, R1 and R2 are each independently H, an alkyl group having 1 to 2 carbon atoms, an alkenyl group having 2 carbon atoms or an alkynyl group or a phenyl group having 2 carbon atoms, n is 2 to 12 and X is an amino acid residue. SELECTED DRAWING: Figure 2 COPYRIGHT: (C)2018,JPOandINPIT

Synthesis of dye-labeled lysine derivatives

The N(ε)-dabcyl-N(α)-(9-fluorenylmethoxy)-carbonyllysine was prepared by reaction of lysine-Cu2+ complex with the N-hydroxysuccinimide (HOSu) activated ester of [4-(4'-dimethylamino)phenylazo]benzoic acid (dabcyl acid) followed by treatment with EDTA and acylation with Fmoc-OSu, and the N(α)tert-butyloxycarbonyl-N(ε)-dabcyllysine was prepared by reaction of N(α)-tertbutyloxycarbonyllysine with dabcyl-OSu.