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Cas Database

146998-31-4

146998-31-4

Identification

  • Product Name:Benzoic acid,4-[2-[4-(dimethylamino)phenyl]diazenyl]-, 2,5-dioxo-1-pyrrolidinyl ester

  • CAS Number: 146998-31-4

  • EINECS:

  • Molecular Weight:366.376

  • Molecular Formula: C19H18N4O4

  • HS Code:29280000

  • Mol File:146998-31-4.mol

Synonyms:4-((4-(Dimethylamino)phenyl)azo)benzoic acid, succinimidyl ester;Dabcylsuccinimidyl ester;2,5-Pyrrolidinedione,1-[[4-[[4-(dimethylamino)phenyl]azo]benzoyl]oxy]- (9CI);

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Safety information and MSDS

Supplier and reference price

  • Manufacture/Brand
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  • Manufacture/Brand:TRC
  • Product Description:4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester
  • Packaging:50mg
  • Price:$ 85
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:N-Succinimidyl 4-[4-(Dimethylamino)phenylazo]benzoate >98.0%(HPLC)(T)
  • Packaging:1g
  • Price:$ 375
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:N-Succinimidyl 4-[4-(Dimethylamino)phenylazo]benzoate >98.0%(HPLC)(T)
  • Packaging:200mg
  • Price:$ 150
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester ≥98.0% (HPLC)
  • Packaging:100 mg
  • Price:$ 238
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester ≥98.0% (HPLC)
  • Packaging:100mg-f
  • Price:$ 231
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Dabcyl-OSu Novabiochem?
  • Packaging:1 g
  • Price:$ 282
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Dabcyl-OSu Novabiochem . CAS 146998-31-4, molar mass 366.37 g/mol., Novabiochem
  • Packaging:8510220001
  • Price:$ 272
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester ≥98.0% (HPLC)
  • Packaging:25 mg
  • Price:$ 81
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester ≥98.0% (HPLC)
  • Packaging:25mg-f
  • Price:$ 78.5
  • Delivery:In stock
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  • Manufacture/Brand:ChemScene
  • Product Description:Dabcylacid,SE 98.72%
  • Packaging:25mg
  • Price:$ 50
  • Delivery:In stock
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Relevant articles and documentsAll total 5 Articles be found

Fluorogenic Bifunctional trans-Cyclooctenes as Efficient Tools for Investigating Click-to-Release Kinetics

de Geus, Mark A. R.,Maurits, Elmer,Sarris, Alexi J. C.,Hansen, Thomas,Kloet, Max S.,Kamphorst, Kiki,ten Hoeve, Wolter,Robillard, Marc S.,Pannwitz, Andrea,Bonnet, Sylvestre A.,Codée, Jeroen D. C.,Filippov, Dmitri V.,Overkleeft, Herman S.,van Kasteren, Sander I.

supporting information, p. 9900 - 9904 (2020/06/05)

The inverse electron demand Diels–Alder pyridazine elimination reaction between tetrazines and allylic substituted trans-cyclooctenes (TCOs) is a key player in bioorthogonal bond cleavage reactions. Determining the rate of elimination of alkylamine substrates has so far proven difficult. Here, we report a fluorogenic tool consisting of a TCO-linked EDANS fluorophore and a DABCYL quencher for accurate determination of both the click and release rate constants for any tetrazine at physiologically relevant concentrations.

ENZYME DETECTION COMPOUND AND MANUFACTURING METHOD OF THE COMPOUND

-

Paragraph 0039, (2018/02/27)

PROBLEM TO BE SOLVED: To obtain a noel compound for detecting enzyme and a detection method of enzyme using the same and a compound having following structure, R1 and R2 are each independently H, an alkyl group having 1 to 2 carbon atoms, an alkenyl group having 2 carbon atoms or an alkynyl group or a phenyl group having 2 carbon atoms, n is 2 to 12 and X is an amino acid residue. SELECTED DRAWING: Figure 2 COPYRIGHT: (C)2018,JPOandINPIT

TUNABLE FLUORESCENCE USING CLEAVABLE LINKERS

-

Paragraph 0070-0071, (2014/11/11)

The invention relates to cleavable chemistry in general, and in particular, to tunable fluoresence using cleavable linkers present in fluorochrome-quencher conjugates.

Multicolor, one- and two-photon imaging of enzymatic activities in live cells with fluorescently quenched activity-based probes (qABPs)

Hu, Mingyu,Li, Lin,Wu, Hao,Su, Ying,Yang, Peng-Yu,Uttamchandani, Mahesh,Xu, Qing-Hua,Yao, Shao Q.

supporting information; experimental part, p. 12009 - 12020 (2011/09/21)

Fluorescence imaging provides an indispensable way to locate and monitor biological targets within complex and dynamic intracellular environments. Of the various imaging agents currently available, small molecule-based probes provide a powerful tool for live cell imaging, primarily due to their desirable properties, including cell permeability (as a result of their smaller sizes), chemical tractability (e.g., different molecular structures/designs can be installed), and amenability to imaging a wide variety of biological events. With a few exceptions, most existing small molecule probes are however not suitable for in vivo bioimaging experiments in which high-resolution studies of enzyme activity and localization are necessary. In this article, we reported a new class of fluorescently Quenched Activity-Based Probes (qABPs) which are highly modular, and can sensitively image (through multiple enzyme turnovers leading to fluorescence signal amplification) different types of enzyme activities in live mammalian cells with good spatial and temporal resolution. We have also incorporated two-photon dyes into our modular probe design, enabling for the first time activity-based, fluorogenic two-photon imaging of enzyme activities. This, hence, expands the repertoire of smart, responsive probes currently available for live cell bioimaging experiments.

Synthesis of dye-labeled lysine derivatives

Shen, Zongxuan,Zhang, Yawen,Chen, Yan

, p. 2525 - 2532 (2007/10/03)

The N(ε)-dabcyl-N(α)-(9-fluorenylmethoxy)-carbonyllysine was prepared by reaction of lysine-Cu2+ complex with the N-hydroxysuccinimide (HOSu) activated ester of [4-(4'-dimethylamino)phenylazo]benzoic acid (dabcyl acid) followed by treatment with EDTA and acylation with Fmoc-OSu, and the N(α)tert-butyloxycarbonyl-N(ε)-dabcyllysine was prepared by reaction of N(α)-tertbutyloxycarbonyllysine with dabcyl-OSu.

Process route upstream and downstream products

Process route

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

p-methyl red
201858-51-7

p-methyl red

4-((4-(dimethylamino)phenyl)azo)benzoic acid succinimidyl ester
146998-31-4,1155356-49-2

4-((4-(dimethylamino)phenyl)azo)benzoic acid succinimidyl ester

Conditions
Conditions Yield
With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 - 20 ℃;
85%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 - 60 ℃;
82%
With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃;
74%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

sodium 4-((4-(dimethylamino)phenyl)diazenyl)benzoate

sodium 4-((4-(dimethylamino)phenyl)diazenyl)benzoate

4-((4-(dimethylamino)phenyl)azo)benzoic acid succinimidyl ester
146998-31-4,1155356-49-2

4-((4-(dimethylamino)phenyl)azo)benzoic acid succinimidyl ester

Conditions
Conditions Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;
62.7%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

p-methyl red
201858-51-7

p-methyl red

4-((4-(dimethylamino)phenyl)azo)benzoic acid succinimidyl ester
146998-31-4,1155356-49-2

4-((4-(dimethylamino)phenyl)azo)benzoic acid succinimidyl ester

Conditions
Conditions Yield
With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 - 20 ℃;
85%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 - 60 ℃;
82%
With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃;
74%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

sodium 4-((4-(dimethylamino)phenyl)diazenyl)benzoate

sodium 4-((4-(dimethylamino)phenyl)diazenyl)benzoate

4-((4-(dimethylamino)phenyl)azo)benzoic acid succinimidyl ester
146998-31-4,1155356-49-2

4-((4-(dimethylamino)phenyl)azo)benzoic acid succinimidyl ester

Conditions
Conditions Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;
62.7%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

Global suppliers and manufacturers

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