147-61-5

Basic information

• Product Name: 5-HYDROXYMETHYL-6-METHYLURACIL
• Synonyms: 3h)-pyrimidinedione,5-(hydroxymethyl)-6-methyl-4(1h;4-methyl-5-hydroxymethyluracil;4-methyl-5-oxymethyluracil;5-(hydroxymethyl)-6-methyl-2,4(1h,3h)-pyrimidinedione;5-(hydroxymethyl)-6-methyl-uraci;5-hydroxymethyl-4-methyluracil;pentoksil;pentoxil
• CAS NO: 147-61-5
• Molecular Formula: C₆H₈N₂O₃
• Molecular Weight: 156.13932
• EINECS: 205-694-0
• Mol File: 147-61-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 280.35°C (rough estimate)
• Flash Point: °C
• Appearance: /
• Density: 1.3889 (rough estimate)
• Refractive Index: 1.5010 (estimate)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-HYDROXYMETHYL-6-METHYLURACIL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-HYDROXYMETHYL-6-METHYLURACIL(147-61-5)
• EPA Substance Registry System: 5-HYDROXYMETHYL-6-METHYLURACIL(147-61-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 147-61-5(Hazardous Substances Data)

Usage

General Description

5-HYDROXYMETHYL-6-METHYLURACIL, also known as 5-Hydroxymethyluracil, is a chemical compound that is derived from uracil. It is a modified base found in the DNA of some viruses, including bacteriophages and poxviruses. 5-Hydroxymethyluracil plays a role in the regulation of gene expression and in the control of viral replication. It has also been studied for its potential antiviral properties and as a target for drug development. Additionally, it has been found to have potential applications in the field of molecular biology and biotechnology. Overall, 5-Hydroxymethyluracil is a significant chemical with various biological and biomedical implications.

InChI:InChI=1/C6H8N2O3/c1-3-4(2-9)5(10)8-6(11)7-3/h9H,2H2,1H3,(H2,7,8,10,11)

Upstream product

• 626-48-2 6-Methyluracil 
• 50-00-0 formaldehyd 
• 84389-04-8 6-Methyl-5-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)-1H-pyrimidine-2,4-dione 
• 66947-91-9 5-(chloromethyl)-6-methyluracil 

Downstream Products

• 66947-91-9 5-(chloromethyl)-6-methyluracil 
• 16768-43-7 2,4-Dichloro-5-chloromethyl-6-methyl-pyrimidine 
• 64-19-7 acetic acid 
• 57-13-6 urea 
• 869891-39-4 2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-4-methyl-6-piperazin-1-ylpyrimidine trifluoroacetic acid salt 
• 869891-32-7 2-(2,6-diethyl-phenyl)-6-methyl-5-{[methyl-(1S)-(1,2,3,4-tetrahydro-naphthalen-1-yl)-amino]-methyl}-pyrimidin-4-ol 
• 869891-37-2 4-[2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-6-methyl-pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester 
• 869891-40-7 2-{4-[2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-6-methyl-pyrimidin-4-yl]-piperazin-1-yl}-acetamide 
• 869891-47-4 2-(2,6-dimethylphenyl)-5-[(5-isopropyl-2-methylphenoxy)methyl]-6-methylpyrimidin-4-ol 
• 869891-45-2 2-chloro-5-[(5-isopropyl-2-methylphenoxy)methyl]-4-methoxy-6-methylpyrimidine 
• 869891-36-1 2,4-dichloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-6-methyl-pyrimidine 

Related news

Reaction of 5-HYDROXYMETHYL-6-METHYLURACIL (cas 147-61-5) with Toluenesulfonyl Chloride or Methanesulfonyl Chloride and Tertiary Amines09/28/2019

Quaternary ammonium salts were formed or the starting uracil was recovered after the reaction of 5-hydroxymethyl-6-methyluracil with toluenesulfonyl chloride or methanesulfonyl chloride and tertiary amines.detailed

Relevant articles and documents

Synthesis of dihydrobenzo[b]pyrimido[4,5-e][1,4]thiazepines; derivatives of a novel ring system

Several derivatives of the novel dihydrobenzo[b]pyrimido[4,5-e][1,4]thiazepine ring system have been synthesised through the initial heterocyclisation of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine with o-aminothiophenol followed by treatment with various secondary amines in boiling ethanol.

Synthesis of 2-substituted-4-methyl-5,13-dihydropyrimido[4′,5′:5,6][1,4]thiazepino[2,3-b]quinoxaline as a new heterocyclic system

2-Substituted-4-methyl-5,13-dihydropyrimido[4′,5′:5,6][1,4]thiazepino[2,3-b]quinoxalines (7a-g), derivatives of a new heterocyclic system were synthesized through cyclocondensation of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine (3) with 3-aminoquinoxaline-2-thiol (4) and subsequent substitution by various secondary amines. Regioselective heterocyclization was confirmed by X-ray crystallographic analysis for 4-methyl-2-(pyrrolidin-1-yl)-5,13-dihydropyrimido[4′,5′:5,6] [1,4]thiazepino[2,3-b]quinoxaline (7a).

Synthesis of the novel bicyclic oxepinopyrimidine and fluorinated pyrrolidinopyrimidines

The new 5,6-disubstituted pyrimidine nucleoside analogues (5-8) were synthesized by addition of the C-6 lithiated pyrimidine derivative to oxirane as key reaction step. The bicyclic tetrahydrooxepinopyrimidine (9) and fluorinated pyrrolidinopyrimidines (12 and 15) were obtained by intramolecular linkage of acyclic chain to the CH2-5 and N-1 of the pyrimidine ring. The structure of compound (9) containing pyrimidine and tetrahydrooxepine skeleton was determined unequivocally by its X-Ray crystal structure analysis.

Regioselective synthesis of new 5-methyl-5H-pyrimido[4′,5′:4,5][1,3]thiazino [3,2-a]perimidines

A convenient and efficient regioselective synthesis of new pyrimido[4′,5′:4,5] [1,3]thiazino[3,2-a]perimidines is described through intermolecular heterocyclization of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine and 1H-perimidine-2(3H)-thione in short reaction times under mild conditions.