147118-39-6Relevant articles and documents
Preparation process of rosuvastatin calcium preparation
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Paragraph 0030; 0033; 0041; 0049, (2018/10/11)
The invention provides a preparation process of a rosuvastatin calcium preparation, and belongs to the technical field of pharmaceutical preparations. With (3R)-tert-butyldimethylsiloxy-5-oxy-6-triphenylphosphoranylidene methyl caproate and 4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonyl amino)pyridine-5-formaldehyde as initial raw materials, wittig reaction, deprotection reaction, chiral reduction reaction, hydrolysis reaction and purification are carried out so as to obtain a rosuvastatin calcium crude drug; then the rosuvastatin calcium crude drug is uniformly mixed with a diluent, a disintegrating agent, a stabilizing agent and a lubricant so as to obtain a mixture, and then the mixture is tabletted so as to obtain the rosuvastatin calcium preparation. The preparation process of the rosuvastatin calcium preparation disclosed by the invention has the advantages of simple operation, high yield, low cost and stable quality.
A rosuvastatin calcium impurity preparation method
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Paragraph 0033; 0037; 0038, (2017/08/26)
The invention discloses a preparation method of a rosuvastatin calcium impurity. The target compound is produced from 4-(4-fluorophenyl)-6-isopropyl-2(N-methyl-methanesulfonylamino)pyrimidine-5-yl]-formaldehyde and methyl (3R)-3-t-butyldimethylsiloxy-5-carbonyl-6-(triphenylphosphinevinyl)caproate through a Witting reaction, HF deprotection, alkaline hydrolysis and an acidifying reaction. The method has the characteristics of short synthesis route, simple operation, convenient post-treatment, and high purity and high yield of the product. The method provides certain help for register reporting of rosuvastatin calcium, production middle control and improvement of the quality of rosuvastatin calcium.
PROCESS FOR THE PREPARATION OF ROSUVASTATIN CALCIUM VIA NOVEL AMINE INTERMEDIATE
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Page/Page column 17, (2012/05/31)
The present invention, relates to novel amine salts of rosuvastatin and its process for the preparation. Moreover, the present invention also relates to improved process for the preparation of rosuvastatin calcium, employing novel amine salts as an intermediate.