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Cas Database

147460-41-1

147460-41-1

Identification

  • Product Name:Phenol,2-bromo-5-fluoro-

  • CAS Number: 147460-41-1

  • EINECS:-0

  • Molecular Weight:191

  • Molecular Formula: C6H4BrFO

  • HS Code:29071990

  • Mol File:147460-41-1.mol

Synonyms:2-bromo-5-fluoro-phenol; 5-fluoro-2-bromophenol; 2-bromo-5-fluorphenol; 2-BroMo-5-fluorophenol;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi,HarmfulXn

  • Hazard Codes:Xi,Xn

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:2-Bromo-5-fluorophenol
  • Packaging:2.5g
  • Price:$ 65
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:2-Bromo-5-fluorophenol >98.0%(GC)
  • Packaging:5g
  • Price:$ 46
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:2-Bromo-5-fluorophenol >98.0%(GC)
  • Packaging:25g
  • Price:$ 148
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:2-Bromo-5-fluorophenol 98%
  • Packaging:100 g
  • Price:$ 197
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:2-Bromo-5-fluorophenol 98%
  • Packaging:25 g
  • Price:$ 112
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:2-Bromo-5-fluorophenol 97%
  • Packaging:5g
  • Price:$ 44.6
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:2-Bromo-5-fluorophenol 97%
  • Packaging:1g
  • Price:$ 27.1
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Bromo-5-fluorophenol 98%
  • Packaging:100g
  • Price:$ 92
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Bromo-5-fluorophenol 98%
  • Packaging:25g
  • Price:$ 23
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Frontier Specialty Chemicals
  • Product Description:2-Bromo-5-fluorophenol 97%
  • Packaging:5g
  • Price:$ 49
  • Delivery:In stock
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Relevant articles and documentsAll total 2 Articles be found

Identification of 4-(4-nitro-2-phenethoxyphenyl)pyridine as a promising new lead for discovering inhibitors of both human and rat 11β-Hydroxylase

Hu, Qingzhong,Kunde, Jessica,Hanke, Nina,Hartmann, Rolf W.

, p. 139 - 150 (2015)

The inhibition of 11β-hydroxylase is a promising strategy for the treatment of Cushing's syndrome, in particular for the recurrent and subclinical cases. To achieve proof of concept in rats, efforts were paid to identify novel lead compounds inhibiting both human and rat CYP11B1. Modifications on a potent promiscuous inhibitor of hCYP11B1, hCYP11B2 and hCYP19 (compound IV) that exhibited moderate rCYP11B1 inhibition led to compound 8 as a new promising lead compound. Significant improvements compared to starting point IV were achieved regarding inhibitory potency against both human and rat CYP11B1 (IC50 values of 2 and 163 nM, respectively) as well as selectivity over hCYP19 (IC50 Combining double low line 1900 nM). Accordingly, compound 8 was around 7-and 28-fold more potent than metyrapone regarding the inhibition of human and rat CYP11B1 and exhibited a comparable selectivity over hCYP11B2 (SF of 3.5 vs 4.9). With further optimizations on this new lead compound 8, drug candidates with satisfying profiles are expected to be discovered.

Preparation of monofluorophenols via the reaction of difluorobenzene derivatives with potassium trimethylsilanoate

Li, Jianqing,Smith, Daniel,Qiao, Jennifer X.,Huang, Stella,Krishnananthan, Subramaniam,Wong, Henry S.,Salvati, Mark E.,Balasubramanian, Balu N.,Chen, Bang-Chi

scheme or table, p. 633 - 637 (2009/07/01)

An efficient synthesis of monofluorophenols via the reaction of difluorobenzene derivatives with potassium trimethylsilanoate in moderate to excellent yields is described. High regioselectivity was observed in some cases. Georg Thieme Verlag Stuttgart.

Process route upstream and downstream products

Process route

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

2-bromo-5-fluorophenol
147460-41-1

2-bromo-5-fluorophenol

Conditions
Conditions Yield
With boron tribromide; In dichloromethane; at -20 - 20 ℃; Inert atmosphere;
2,4-difluorobromobenzene
348-57-2

2,4-difluorobromobenzene

4-bromo-3-fluorophenol
121219-03-2

4-bromo-3-fluorophenol

2-bromo-5-fluorophenol
147460-41-1

2-bromo-5-fluorophenol

Conditions
Conditions Yield
2,4-difluorobromobenzene; With potassium trimethylsilonate; In diethylene glycol dimethyl ether; at 120 ℃; for 5h; Inert atmosphere;
With hydrogenchloride; In diethylene glycol dimethyl ether; water; at 20 ℃; Inert atmosphere;
1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

2-bromo-5-fluorophenol
147460-41-1

2-bromo-5-fluorophenol

Conditions
Conditions Yield
With boron tribromide; In dichloromethane; at -20 - 20 ℃; Inert atmosphere;
2,4-difluorobromobenzene
348-57-2

2,4-difluorobromobenzene

4-bromo-3-fluorophenol
121219-03-2

4-bromo-3-fluorophenol

2-bromo-5-fluorophenol
147460-41-1

2-bromo-5-fluorophenol

Conditions
Conditions Yield
2,4-difluorobromobenzene; With potassium trimethylsilonate; In diethylene glycol dimethyl ether; at 120 ℃; for 5h; Inert atmosphere;
With hydrogenchloride; In diethylene glycol dimethyl ether; water; at 20 ℃; Inert atmosphere;

Global suppliers and manufacturers

Global( 99) Suppliers
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  • Simagchem Corporation
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  • Amadis Chemical Co., Ltd.
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  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
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  • Country:China (Mainland)
  • Chemwill Asia Co., Ltd.
  • Business Type:Manufacturers
  • Contact Tel:021-51086038
  • Emails:sales@chemwill.com
  • Main Products:30
  • Country:China (Mainland)
  • Shaanxi BLOOM TECH Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-29-86470566
  • Emails:sales@bloomtechz.com
  • Main Products:80
  • Country:China (Mainland)
  • Shanghai Upbio Tech Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-21-52196435
  • Emails:upbiocn@hotmail.com
  • Main Products:88
  • Country:China (Mainland)
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