1482-50-4

Basic information

• Product Name: 11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE
• Synonyms: 11,17,21-trihydroxy-,(5beta,11beta)-pregnane-20-dione;11-beta,17,21-trihydroxy-5-beta-pregnane-20-dione;11-beta,17,21-trihydroxy-5-beta-pregnane-3,20-dione;dihydrocortisol;11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE;5-BETA-PREGNAN-11-BETA, 17,21-TRIOL-3,20-DIONE;5BETA-PREGNAN-11BETA,17ALPHA,21-TRIOL-3,20-DIONE;5-BETA-DIHYDROCORTISOL
• CAS NO: 1482-50-4
• Molecular Formula: C₂₁H₃₂O₅
• Molecular Weight: 364.48
• Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 1482-50-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 544.5°Cat760mmHg
• Flash Point: 297.1°C
• Appearance: /
• Density: 1.249g/cm³
• Refractive Index: 1.569
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE(1482-50-4)
• EPA Substance Registry System: 11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE(1482-50-4)

Safety Data

• Hazardous Substances Data: 1482-50-4(Hazardous Substances Data)

Usage

Uses

5β-Dihydrocortisol, is a derivative of Cortisol (H714615), which is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland.

InChI:InChI=1/C21H32O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12,14-16,18,22,24,26H,3-11H2,1-2H3/t12?,14-,15-,16-,18+,19-,20-,21-/m0/s1

Upstream product

• 50-23-7 HYDROCORTISONE 
• 53-57-6 NADPH 
• 312-99-2 17α-21-dihydroxy-5-α-pregnane-3,20-dione 
• 1639-45-8 21-acetoxy-17α-hydroxy-5α-pregnane-3,20-dione 
• 50-03-3 hydrocortisone acetate 
• 64313-94-6 RU 18760 

Downstream Products

• 739-26-4 11β-hydroxyetiocholanolone 
• 1429-06-7 5β-androstane-3,11,17-trione 
• 64313-94-6 RU 18760 
• 53-02-1 tetrahydrocortisol 
• 36623-16-2 tetrahydrocortisone 3-acetate 

Relevant articles and documents

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NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF

Described herein are neuroactive steroids of the Formula (I): (Formula (I)) or a pharmaceutically acceptable salt thereof; wherein R1a and R1b are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

METHODS FOR THE PURIFICATION OF DEOXYCHOLIC ACID

Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12-α-hydroxy-steroids from Δ-9,11-ene, 11-keto or 11-hydroxy-β-steroids. This invention is also directed to novel compounds prepared during the synthesis. This invention is also directed to the synthesis of deoxycholic acid starting from hydrocortisone.