14845-41-1Relevant articles and documents
POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF HIV INFECTIONS
-
Page/Page column 68; 69; 70, (2015/02/02)
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R1, R5/s
Photoinduced Electron Transfer Reactions of α-Cyclopropyl- And α-Epoxy Ketones. Tandem Fragmentation-Cyclization to Bi-, Tri-, and Spirocyclic Ketones
Kirschberg, Thorsten,Mattay, Jochen
, p. 8885 - 8896 (2007/10/03)
Reductive photoinduced electron transfer (PET) reactions have been performed with various bicyclic a-cyclopropyl-substituted ketones and tertiary amines. The reaction resulted in a regioselective cleavage of one cyclopropyl bond under formation of an exocyclic radical with an endocyclic enolate unit. In the case of bicyclic ketones with an unsaturated side chain, various bicyclic, spirocyclic, and tricyclic products are accessible via radical cyclization, depending on the position of the alkenyl substituent. In addition to triethylamine, W-silylated amines have also been used as electron donors, leading to a variety of compounds, among them are silylated fragmentation products, indicating that a proton is transferred from not only the amine radical cation but also the cationic silyl group. The intramolecular Paternoe-Buechi reaction has also been studied for cyclopropane derivatives of the jasmone type leading to tetracyclic oxetanes. Finally, α-epoxy-substituted ketones have been investigated under PET conditions, yielding ring-opened products.
Chemical Transformation of Terpenoids. VII. Syntheses of Chiral Segments, Key Building-Blocks for the Right Half of Taxane-Type Diterpenoids
Shibuya, Hirotaka,Tsujii, Shinji,Yamamoto, Yoshio,Miura, Hiromi,Kitagawa, Isao
, p. 3417 - 3427 (2007/10/02)
Two kinds of chiral segments, i.e. segment B-I (4) and segment B-II (5), which are potentially versatile building-blocks for construction of the right half of taxane-type diterpenoids, were synthesized from 3-methyl-2-cyclohexen-1-one (6) via optical reso