14850-89-6

Basic information

• Product Name: Benzoic acid, (2E)-(phenylmethylene)hydrazide
• CAS NO: 14850-89-6
• Molecular Formula: C14H12N2O
• Molecular Weight: 224.262
• Mol File: 14850-89-6.mol
• Article Data: 78

Chemical Properties

• CAS DataBase Reference: Benzoic acid, (2E)-(phenylmethylene)hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, (2E)-(phenylmethylene)hydrazide(14850-89-6)
• EPA Substance Registry System: Benzoic acid, (2E)-(phenylmethylene)hydrazide(14850-89-6)

Safety Data

• Hazardous Substances Data: 14850-89-6(Hazardous Substances Data)

Upstream product

• 5281-18-5 benzaldehyde, hydrazone 
• 93-89-0 benzoic acid ethyl ester 
• 60339-73-3 N'-benzylidene-benzohydrazonoyl azide 
• 141-52-6 sodium ethanolate 
• 538-51-2 benzylidene phenylamine 
• 613-94-5 benzoic acid hydrazide 
• 100-52-7 benzaldehyde 
• 19179-24-9 N-Hydroperoxymethyl-N'-benzoylhydrazin 
• 6830-78-0 3,6-diphenyl-1,2,4,5-tetrazine 
• 4335-90-4 3-benzylidene acetylacetone 
• 57492-77-0 7-benzoylamino-6-methyl-[1,3]dioxolo[4,5-g]quinazolinium betaine 
• 109-73-9 N-butylamine 
• 7732-18-5 water 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1924-86-3 benzaldehyde N-methyl-N-benzoylhydrazone 
• 934832-26-5 N'-(1-phenylbut-3-en-1-yl)benzohydrazide 
• 725-12-2 2,5-bis-(phenyl)-1,3,4-oxadiazole 
• 105251-34-1 (3S*,4S*)-4-amino-3-methyl-4-phenyl-1-butene 
• 77420-85-0 1,4-diphenyl-1-ethylxanthyl-2,3-diazabutadiene 
• 100-52-7 benzaldehyde 
• 613-94-5 benzoic acid hydrazide 
• 595566-02-2 (1R,2R)-N'-(2-methyl-1-phenylbut-3-enyl)benzohydrazide 
• 934762-76-2 C₁₈H₂₀N₂O 
• 1192114-61-6 (1S,2R)-N'-(2-chloro-1-phenylbut-3-enyl)benzohydrazide 
• 1192114-62-7 (1R,2S)-N'-(2-chloro-1-phenylbut-3-enyl)benzohydrazide 
• 1236310-01-2 C₁₈H₁₆N₂O₂ 
• 1236309-93-5 C₁₈H₁₆N₂O₂ 

Relevant articles and documents

Analogs of Nitrofuran Antibiotics to Combat Resistance

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Modulation of estrogen-related receptors subtype selectivity: Conversion of an ERRβ/γ selective agonist to ERRα/β/γ pan agonists

Estrogen Related Receptors (ERRs) are key regulators of energy homeostasis and play important role in the etiology of metabolic disorders, skeletal muscle related disorders, and neurodegenerative diseases. Among the three ERR isoforms, ERRα emerged as a potential drug target for metabolic and neurodegenerative diseases. Although ERRβ/γ selective agonist chemical tools have been identified, there are no chemical tools that effectively target ERRα agonism. We successfully engineered high affinity ERRα agonism into a chemical scaffold that displays selective ERRβ/γ agonist activity (GSK4716), providing novel ERRα/β/γ pan agonists that can be used as tools to probe the physiological roles of these nuclear receptors. We identified the structural requirements to enhance selectivity toward ERRα. Molecular modeling shows that our novel modulators have favorable binding modes in the LBP of ERRα and can induce conformational changes where Phe328 that originally occupies the pocket is dislocated to accommodate the ligands in a rather small cavity. The best agonists up-regulated the expression of target genes PGC-1α and PGC-1β, which are necessary to achieve maximal mitochondrial biogenesis. Moreover, they increased the mRNA levels of PDK4, which play an important role in energy homeostasis.

Synthesis and biological evaluation in vitro and in silico of N-propionyl-N′-benzeneacylhydrazone derivatives as cruzain inhibitors of Trypanosoma cruzi

Abstract: An N-acylhydrazone scaffold has been used to develop new drugs with diverse biological activities, including trypanocidal activity against different strains of Trypanosoma cruzi. However, their mechanism of action is not clear, although in T. cr