14916-65-5

Basic information

• Product Name: 5-AMINO-2-NITROPYRIDINE
• Synonyms: 5-AMINO-2-NITROPYRIDINE;3-Amino-6-nitropyridine;3-Pyridinamine,6-nitro-(9CI);6-Nitropyridin-3-amine;2-Nitro-5-pyridinamine;6-Nitro-pyridin-3-ylamine;5-Amino-2-nitropyridine 95%;6-nitro-3-PyridinaMine
• CAS NO: 14916-65-5
• Molecular Formula: C₅H₅N₃O₂
• Molecular Weight: 139.11
• Product Categories: NITRO;Pyridines;Building Blocks;Pyridine;Heterocycle-Pyridine series
• Mol File: 14916-65-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 234-235 °C (decomp)(Solv: benzene (71-43-2))
• Boiling Point: 382.9°Cat760mmHg
• Flash Point: 185.4°C
• Appearance: /
• Density: 1.437g/cm³
• Vapor Pressure: 4.57E-06mmHg at 25°C
• Refractive Index: 1.645
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -1.02±0.10(Predicted)
• CAS DataBase Reference: 5-AMINO-2-NITROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-2-NITROPYRIDINE(14916-65-5)
• EPA Substance Registry System: 5-AMINO-2-NITROPYRIDINE(14916-65-5)

Safety Data

• Hazardous Substances Data: 14916-65-5(Hazardous Substances Data)

Usage

Uses

6-Nitropyridin-3-amine is used in preparation of dihydroquinazoline compounds as NAV1.8 inhibitors.

InChI:InChI=1/C5H5N3O2/c6-4-1-2-5(7-3-4)8(9)10/h1-3H,6H2

Upstream product

• 52092-47-4 5-chloro-2-nitropyridine 
• 39856-50-3 5-bromo2-nitropyridine 
• 64-17-5 ethanol 
• 7664-41-7 ammonia 

Downstream Products

• 1451274-39-7 5-bromo-2-methoxy-N-(6-nitropyridin-3-yl)benzenesulfonamide 
• 1184614-21-8 5-bromo-2-methoxy-N-(6-aminopyridin-3-yl)benzenesulfonamide 

Relevant articles and documents

SULFONAMIDE COMPOUNDS AND USES AS TNAP INHIBITORS

Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper- mineralization.

Synthetic Approaches to some Aza-analogues of Benzimidazole N-Oxides. Part 1. The Imidazopyridine Series

The 3-oxide of 2-p-nitrophenylimidazopyridine (8) may be obtained in good yield by base-induced cyclisation of 2-nitro-3-(p-nitrobenzylamino)pyridine (18).It is also obtained in lower yield, along with p-nitrobenzoic acid and other cleavage products, by the corresponding reactions of bases with the N-ethoxycarbonyl, N-methylsulphonyl, and N-p-tolylsulphonyl derivatives of 2-nitro-3-(p-nitrobenzylamino)pyridine .Cleavage is the main reaction when N-(2-nitro-3-pyridyl)-N-phenacylmethanesulphonamide (17) is treated with bases: phenylglyoxal, or its Schiff base with 3-amino-2-nitropyridine, are possible intermediates in the cleavage process. 3-Nitro-2-(p-nitrobenzylamino)pyridine (31) is similarly cyclised in basic media to give the 1-oxide of 2-p-nitrophenylimidazopyridine (32).