1-O-(trimethylsilyl)-4,6-O-ethylidene-2,3-di-O-(dichloroacetyl)-β-D-glucopyranose is a complex organic compound that serves as a key intermediate in the synthesis of various pharmaceuticals. It is characterized by its unique chemical structure, which includes a trimethylsilyl group, an ethylidene bridge, and dichloroacetyl moieties attached to a β-D-glucopyranose backbone. This structure endows the compound with specific reactivity and properties that make it valuable in the development of therapeutic agents.

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Basic information
1. Product Name: 1-O-(trimethylsilyl)-4,6-O-ethylidene-2,3-di-O-(dichloroacetyl)-β-D-glucopyranose
2. Synonyms: 1-O-(trimethylsilyl)-4,6-O-ethylidene-2,3-di-O-(dichloroacetyl)-β-D-glucopyranose
3. CAS NO:149312-24-3
4. Molecular Formula:
5. Molecular Weight: 500.232
6. EINECS: N/A
7. Product Categories: N/A
8. Mol File: 149312-24-3.mol
Chemical Properties
1. Melting Point: N/A
2. Boiling Point: N/A
3. Flash Point: N/A
4. Appearance: N/A
5. Density: N/A
6. Refractive Index: N/A
7. Storage Temp.: N/A
8. Solubility: N/A
9. CAS DataBase Reference: 1-O-(trimethylsilyl)-4,6-O-ethylidene-2,3-di-O-(dichloroacetyl)-β-D-glucopyranose(CAS DataBase Reference)
10. NIST Chemistry Reference: 1-O-(trimethylsilyl)-4,6-O-ethylidene-2,3-di-O-(dichloroacetyl)-β-D-glucopyranose(149312-24-3)
11. EPA Substance Registry System: 1-O-(trimethylsilyl)-4,6-O-ethylidene-2,3-di-O-(dichloroacetyl)-β-D-glucopyranose(149312-24-3)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 149312-24-3(Hazardous Substances Data)

149312-24-3 Usage

Uses

Used in Pharmaceutical Synthesis:
1-O-(trimethylsilyl)-4,6-O-ethylidene-2,3-di-O-(dichloroacetyl)-β-D-glucopyranose is used as an intermediate in the synthesis of Etoposide (E933750), a potent anticancer drug. Its unique structure allows for the efficient construction of the Etoposide molecule, which is effective against a range of cancers, including testicular, lung, and prostate cancer. The compound's role in the synthesis process is crucial for the production of this life-saving medication.
Used in Anticancer Applications:
As an intermediate in the synthesis of Etoposide, 1-O-(trimethylsilyl)-4,6-O-ethylidene-2,3-di-O-(dichloroacetyl)-β-D-glucopyranose indirectly contributes to the development of anticancer treatments. Etoposide is known for its ability to inhibit topoisomerase II, an enzyme essential for DNA replication, thereby disrupting cancer cell division and growth.
Used in Drug Delivery Systems:
While not directly used as a drug delivery system, 1-O-(trimethylsilyl)-4,6-O-ethylidene-2,3-di-O-(dichloroacetyl)-β-D-glucopyranose plays a vital role in the development of novel drug delivery systems for Etoposide. By improving the synthesis and formulation of Etoposide, researchers can explore various drug delivery platforms, such as nanoparticles and liposomes, to enhance the drug's bioavailability, targeting, and therapeutic efficacy.

Check Digit Verification of cas no

The CAS Registry Mumber 149312-24-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,3,1 and 2 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 149312-24:
(8*1)+(7*4)+(6*9)+(5*3)+(4*1)+(3*2)+(2*2)+(1*4)=123
123 % 10 = 3
So 149312-24-3 is a valid CAS Registry Number.

149312-24-3Upstream product

149312-24-3Downstream Products

33419-42-0 etoposide

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CAS

149312-24-3