14984-68-0

Basic information

• Product Name: Cloperastine hydrochloride
• Synonyms: 1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)-piperidinhydrochloride;1-(2-(p-cloro-alpha-fenilbenzilossi)etil)piperidinacloridrato;2-piperidinoethylp-chlorobenzhydryletherhydrochloride;cloperastinacloridrato;ht11;hustazol;4-CHLOROBENZHYDRYL 2-[1-PIPERIDYL]-ETHYL ETHER HYDROCHLORIDE;1-[2-[(4-chlorophenyl)phenylmethoxy]ethyl]piperidinium chloride
• CAS NO: 14984-68-0
• Molecular Formula: C₂₀H₂₄ClNO*ClH
• Molecular Weight: 366.32
• EINECS: 239-067-8
• Mol File: 14984-68-0.mol

Chemical Properties

• Melting Point: 147.9°
• Boiling Point: 423.9 °C at 760 mmHg
• Flash Point: 210.2 °C
• Appearance: /
• Vapor Pressure: 2.15E-07mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Merck: 14,2395
• CAS DataBase Reference: Cloperastine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Cloperastine hydrochloride(14984-68-0)
• EPA Substance Registry System: Cloperastine hydrochloride(14984-68-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36
• WGK Germany: 3
• RTECS: TM6491500
• Hazardous Substances Data: 14984-68-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Cloperastine hydrochloride is used as an anti-tussive agent for the treatment of coughs. It helps to suppress the cough reflex by blocking the action of histamine, providing relief from coughing associated with colds and other respiratory conditions.
Cloperastine hydrochloride is also used as a histamine antagonist in the treatment of allergies. By inhibiting the effects of histamine, it can help to alleviate symptoms such as itching, redness, and swelling associated with allergic reactions.
Used in Over-the-Counter Cold Medicine:
Cloperastine hydrochloride is used as an active ingredient in over-the-counter cold medicines. It is particularly effective in providing relief from coughing and other respiratory symptoms caused by colds and flu. Its inclusion in these products helps to reduce the severity and duration of coughing, allowing for a more comfortable recovery process.

InChI:InChI=1/C20H24ClNO.ClH/c21-19-11-9-18(10-12-19)20(17-7-3-1-4-8-17)23-16-15-22-13-5-2-6-14-22;/h1,3-4,7-12,20H,2,5-6,13-16H2;1H

Synthetic route

Cloperastine hydrochloride (14984-68-0) → 1-[2-[(4-chlorophenyl)phenylmethoxy]ethyl]piperidinone

Conditions	Yield
With water; oxygen; sodium hydroxide In tetrahydrofuran at 60℃; under 760.051 Torr; for 24h; Green chemistry; regioselective reaction;	93%

Upstream product

• 3040-44-6 1-piperidinoethanol 
• 134-83-8 1-chloro-4-(chloro(phenyl)methyl)benzene 
• 1932-03-2 2-(piperidin-4-yl)ethyl chloride 
• 119-56-2 (4-chlorophenyl)phenylmethanol 

Related news

Effects of solid-state reaction between paracetamol and Cloperastine hydrochloride (cas 14984-68-0) on the pharmaceutical properties of their preparations07/16/2019

Tablets containing both paracetamol (PM) and cloperastine hydrochloride (CLH) in a combination formulation prepared by standard vertical granulation technology were found to have altered pharmaceutical properties. The hardness and disintegration time of tablets containing both PM and CLH gradual...detailed

Relevant articles and documents

Preparation method of cloperadine hydrochloride

The invention relates to a preparation method of cloperadine hydrochloride, which comprises the following steps: placing a formula VI and a formula III in a solvent or without a solvent, carrying out condensation or etherification reaction, and separating to obtain 1-[2-[(4-chloro-alpha phenyl benzyl) oxygen] ethyl] piperidine (II); and salifying the 1-[2-[(4-chloro-alpha phenyl benzyl) oxygen] ethyl] piperidine with hydrogen chloride or hydrochloric acid in a solvent to obtain the cloperadine hydrochloride. The method is mild in process condition, convenient and simple to operate and suitable for large-scale industrial production, the purity of the produced target product reaches 99.7% or above, and the single impurity is smaller than 0.1%.