149965-41-3

Basic information

• Product Name: 4-bromo-2-(bromomethyl)-1-chlorobenzene
• Synonyms: 4-bromo-2-(bromomethyl)-1-chlorobenzene;5-Bromo-2-chlorobenzyl bromide
• CAS NO: 149965-41-3
• Molecular Formula: C₇H₅Br₂Cl
• Molecular Weight: 284.3756
• Mol File: 149965-41-3.mol

Chemical Properties

• Boiling Point: 286.531 °C at 760 mmHg
• Flash Point: 140.402 °C
• Appearance: /
• Density: 1.933
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-bromo-2-(bromomethyl)-1-chlorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-2-(bromomethyl)-1-chlorobenzene(149965-41-3)
• EPA Substance Registry System: 4-bromo-2-(bromomethyl)-1-chlorobenzene(149965-41-3)

Safety Data

• Hazardous Substances Data: 149965-41-3(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
4-bromo-2-(bromomethyl)-1-chlorobenzene is utilized as a key intermediate in organic synthesis for its ability to participate in various chemical reactions, facilitating the creation of a wide range of organic compounds.
Used in Pharmaceutical Manufacturing:
In the pharmaceutical industry, 4-bromo-2-(bromomethyl)-1-chlorobenzene is employed as a crucial intermediate. Its unique structure allows it to be a component in the synthesis of diverse medicinal compounds, contributing to the development of new drugs.
Used in Agricultural Chemical Production:
Similarly, in agricultural chemistry, this compound is used as an intermediate. Its reactivity and structural features make it suitable for the synthesis of agrochemicals, including pesticides and other crop protection agents.
Used in Research and Development:
4-bromo-2-(bromomethyl)-1-chlorobenzene also plays a role in research and development settings, where its properties are studied and harnessed to understand and innovate within the realms of organic chemistry and related fields.

Upstream product

• 54932-72-8 2-chloro-5-bromotoluene 
• 149965-40-2 5-bromo-2-chlorobenzyl alcohol 
• 21739-92-4 5-bromo-2-chlorobenzoic acid 
• 7789-60-8 phosphorus tribromide 
• 583-75-5 4-Bromo-2-methylaniline 
• 95-53-4 o-toluidine 

Downstream Products

• 960409-48-7 5-bromo-2-chloro-3-[[1,1-dimethylethyl]thiomethyl]benzene 
• 1256557-86-4 2-{[(5-bromo-2-chlorophenyl)methyl]sulfanyl}-6-methylpyrimidin-4-ol 
• 461432-23-5 4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]benzene 
• 915095-89-5 (S)-4-bromo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)benzene 
• 258885-61-9 4-(2-chloro-5-phenylbenzyl)-5-methoxy-2-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 258885-59-5 4-(5-bromo-2-chlorobenzyl)-5-methoxy-2-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 864070-44-0 empagliflozin 
• 1279691-36-9 (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol 
• 1057216-52-0 C₈H₅BrClN 
• 203314-33-4 C₉H₈BrClO₂ 
• 177985-34-1 5-bromo-2-chlorophenylacetic acid 

Relevant articles and documents

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The invention relates to a preparation method of a SGLT2 inhibitor-empagliflozin. The preparation method includes: using 2-methylaniline as a starting raw material, subjecting the starting raw material to bromination, diazotization, chlorination and bromination, and enabling the starting raw material to be in friedel-crafts alkylation reaction with (S)-3-phenoxy tetrahydrofuran to obtain an intermediate-(S)-3-(4-(5-bromo-2-chlorobenzyl)phenoxy) tetrahydrofuran; subjecting the intermediate and 2, 3, 4, 6-tetra-O-trimethylsilyl-D-glucolactone to condensation, etherification and methoxy removal.The preparation method has the advantages that compared with existing synthetic methods, 2-methylaniline is used as the starting raw material, so that the raw material is low in cost and easy to get,the process is easy for industrialization, and a synthetic route is short and easy to operate; in the process of preparation, temperature conditions are easy to control, reaction conversion rate is high, and total yield is up to higher than 75%. In addition, through the preparation method, the inhibitor is less prone to isomerization, impurities are few, and purity of the inhibitor can be improvedto higher than 99%.

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