149977-36-6Relevant articles and documents
Guanidine-containing compound as well as preparation method and application thereof
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Paragraph 0082-0085, (2021/11/26)
The invention discloses a cyanoguanidine-containing compound as well as a preparation method and application thereof. The invention also discloses a composition containing the cyanoguanidine-structured compound (I) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. The invention also discloses application thereof in preparation of analgesic drugs. The compounds of the invention are useful in the treatment of various pain.
Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors
Chen, Xuxing,Huan, Xiajuan,Liu, Qiufeng,Wang, Yuqin,He, Qian,Tan, Cun,Chen, Yi,Ding, Jian,Xu, Yechun,Miao, Zehong,Yang, Chunhao
supporting information, p. 389 - 403 (2018/01/17)
The nuclear protein poly(ADP-ribose) polymerases-1/2 (PARP-1/2) are involved in DNA repair damaged by endogenous or exogenous process. And PARP-1/2 inhibitors have been proved to be clinically efficacious for DNA repair deficient tumors in the past decade
MU OPIOID RECEPTOR MODULATORS
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Paragraph 0416; 0441; 0442, (2018/07/31)
Described herein, inter alia, are compositions and methods for modulating mu opioid receptor activity.