150931-59-2

Basic information

• Product Name: (2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methoxycarbonylmethyl-pyrrolidine-1-carboxylic acid benzyl ester
• CAS NO: 150931-59-2
• Molecular Weight: 407.582
• Mol File: 150931-59-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methoxycarbonylmethyl-pyrrolidine-1-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methoxycarbonylmethyl-pyrrolidine-1-carboxylic acid benzyl ester(150931-59-2)
• EPA Substance Registry System: (2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methoxycarbonylmethyl-pyrrolidine-1-carboxylic acid benzyl ester(150931-59-2)

Safety Data

• Hazardous Substances Data: 150931-59-2(Hazardous Substances Data)

Upstream product

• 207113-34-6 [(2S,3R)-1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-2-yl]-acetic acid methyl ester 
• 150931-62-7 (R)-1-benzyloxycarbonyl-3-(t-butyldimethylsilyloxy)pyrrolidine 
• 150931-63-8 (R)-4-(tert-Butyl-dimethyl-silanyloxy)-3,4-dihydro-2H-pyrrole 1-oxide 
• 159330-31-1 (R)-3-[(1,1-dimethylethyl)dimethylsilyloxy]-pyrrolidine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 95456-65-8 (1R,5R)-(-)-6-aza-6-benzyloxycarbonyl-2-oxabicyclo[3.3.0]octan-3-one 
• 207113-35-7 methyl (2S,3R)-(1-benzyloxycarbonyl-3-hydroxypyrrolidin-2-yl)acetate 
• 136599-33-2 (1S,5S)-(+)-6-aza-6-benzyloxycarbonyl-2-oxabicyclo[3.3.0]octan-3-one 
• 186422-62-8 (1S,5S)-(-)-6-aza-2-oxabicyclo[3.3.0]octan-3-one 

Relevant articles and documents

Synthesis of (R)- and (S)-3-(tert-butyldimethylsilyloxy)-1-pyrroline N- oxides - Chiral nitrones for synthesis of biologically active pyrrolidine derivative, Geissman-Waiss lactone

Tungstate-catalyzed oxidation of O-tert-butyldimethylsilyl (O-TBDMS) protected (R)-3-hydroxypyrrolidine ((R)2), derived from trans-4-hydroxy-L- proline, gave O-TBDMS protected (R)-3-hydroxy-1-pyrroline N-oxide ((R)1), which is a new chiral precursor for the synthesis of Geissman-Waiss lactone. The enantiomeric nitrone (S)-1 was also prepared by the oxidation of (S)-2 derived from L-malic acid.