152456-66-1

Basic information

• Product Name: N-(3-ethylphenyl)-3-oxobutyramide
• Synonyms: N-(3-ethylphenyl)-3-oxobutyramide
• CAS NO: 152456-66-1
• Molecular Weight: 205.257
• Mol File: 152456-66-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 388.1±35.0 °C(Predicted)
• Density: 1.106±0.06 g/cm3(Predicted)
• CAS DataBase Reference: N-(3-ethylphenyl)-3-oxobutyramide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-ethylphenyl)-3-oxobutyramide(152456-66-1)
• EPA Substance Registry System: N-(3-ethylphenyl)-3-oxobutyramide(152456-66-1)

Safety Data

• Hazardous Substances Data: 152456-66-1(Hazardous Substances Data)

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 587-02-0 m-ethylaniline 
• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 

Downstream Products

• 161095-63-2 3-benzyl-7-ethyl-4-methyl-1-<(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl)methyl>-1,2-dihydroquinolin-2-one 
• 161095-62-1 7-ethyl-3,4-dimethyl-1-<(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl)methyl>-1,2-dihydroquinolin-2-one 
• 152456-74-1 7-ethyl-4-methyl-1-<(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl)methyl>-1,2-dihydroquinolin-2-one 
• 152456-45-6 2-<4-((7-ethyl-4-methyl-3-(4-nitrobenzyl)-2-oxo-1,2-dihydroquinolin-1-yl)methyl)phenyl>benzonitrile 
• 152456-48-9 2-<1-((2'-cyanobiphenyl-4-yl)methyl)-7-ethyl-4-methyl-2-oxo-1,2-dihydroquinolin-3-yl>-N,N-dimethylacetamide 
• 152456-46-7 methyl 2-<1-((2'-cyanobiphenyl-4-yl)methyl)-7-ethyl-4-methyl-2-oxo-1,2-dihydroquinolin-3-yl>acetate 
• 152456-67-2 7-ethyl-4-methyl-3-(4-nitrobenzyl)-1,2-dihydroquinolin-2-one 
• 161095-59-6 3-benzyl-7-ethyl-4-methyl-1,2-dihydroquinolin-2-one 
• 152456-68-3 N-(3-ethylphenyl)-2-(4-nitrobenzyl)-3-oxobutyramide 
• 161095-57-4 2-acetyl-N-(3-ethylphenyl)-N',N'-dimethylsuccinamide 
• 161095-56-3 methyl 3--4-oxopentanoate 
• 161095-55-2 2-benzyl-N-(3-ethylphenyl)-3-oxobutyramide 
• 161095-54-1 N-(3-ethylphenyl)-2-methyl-3-oxobutyramide 
• 161095-71-2 2-cyanomethyl-N-(3-ethylphenyl)-3-oxobutyramide 

Relevant articles and documents

Ru-NHC-Catalyzed Asymmetric Hydrogenation of 2-Quinolones to Chiral 3,4-Dihydro-2-Quinolones

Direct enantioselective hydrogenation of unsaturated compounds to generate chiral three-dimensional motifs is one of the most straightforward and important approaches in synthetic chemistry. We realized the Ru(II)-NHC-catalyzed asymmetric hydrogenation of 2-quinolones under mild reaction conditions. Alkyl-, aryl- and halogen-substituted optically active dihydro-2-quinolones were obtained in high yields with moderate to excellent enantioselectivities. The reaction provides an efficient and atom-economic pathway to construct simple chiral 3,4-dihydro-2-quinolones. The desired products could be further reduced to tetrahydroquinolines and octahydroquinolones.