153226-99-4Relevant articles and documents
Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease
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, (2008/06/13)
This invention provides methods for the treatment or prevention of Alzheimer's disease which comprises administering to a mammal in need thereof an effective amount of a compound having activity as a leukotriene antagonist.
SUBSTITUTED PHENYL PHENOL LEUKOTRIENE ANTAGONISTS
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, (2008/06/13)
Antagonists having a substituted phenyl phenol or a substituted phenolic biphenyl structure, and various derivatives thereof, are specific leukotriene antagonists. Their structures, use and synthesis are disclosed. Also, pharmaceutical formulations are disclosed for use in applications treating diseases or conditions characterized by excessive release of leukotriene B 4, one of the metabolites of arachidonic acid.The primary LTB 4 antagonistic structures are represented as: STR1
USE OF PLA2 INHIBITORS AS TREATMENT FOR ALZHEIMER'S DISEASE
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, (2008/06/13)
This invention provides methods for the treatment or prevention of Alzheimer's disease in a mammal which comprises administering to a mammal in need thereof an effective amount of an inhibitor of phospholipase A2. This invention also provides a series of compounds which are useful as inhibitors of phospholipases A2, especially cytosolic phospholipase A2.