153355-70-5

Basic information

• Product Name: Ginkgolide K
• Synonyms: 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)-2,3,10a,11-tetrahydro-4,11-dihydroxy-8-methyl-, (1R,3S,3aS,4R,6aR,7aS,10aR,11R,11aR)-
• CAS NO: 153355-70-5
• Molecular Formula: C20H22O9
• Molecular Weight: 406.38
• Mol File: 153355-70-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 743.5±60.0 °C(Predicted)
• Appearance: /
• Density: 1.60±0.1 g/cm3(Predicted)
• PKA: 12.10±0.70(Predicted)
• CAS DataBase Reference: Ginkgolide K(CAS DataBase Reference)
• NIST Chemistry Reference: Ginkgolide K(153355-70-5)
• EPA Substance Registry System: Ginkgolide K(153355-70-5)

Safety Data

• Hazardous Substances Data: 153355-70-5(Hazardous Substances Data)

Usage

General Description

Ginkgolide K is a natural chemical compound found in Ginkgo biloba, a tree native to China. It falls under the class of diterpene lactones and has been identified as a potent inhibitor of platelet-activating factor, an important mediator of inflammation and asthma. Ginkgolide K has been studied for its potential therapeutic effects in various conditions, including neurological disorders, cardiovascular diseases, and inflammatory conditions. It has been shown to have anti-inflammatory, antioxidant, and neuroprotective properties, making it a promising candidate for the development of new drugs for these conditions. Additionally, ginkgolide K has been found to promote healthy blood circulation and improve cognitive function, further highlighting its potential as a beneficial compound for human health.

Upstream product

• 130523-06-7 1-(tert-butyldiphenylsilyloxy)-3,10-dihydroxyginkgolid 
• 15291-77-7 ginkgolide B 
• 153355-69-2 1-(tert-butyldiphenylsilyloxy)-10-hydroxy-3,14-didehydroginkgolid 

Relevant articles and documents

A preparation method of Ginkgolide K

The invention discloses a method for preparing ginkgolide K. The method includes the following steps: 1, ginkgolide B is dissolved into organic solvents to obtain a solution; 2, fluorinating agents are added into the solution obtained in the step 1 for conducting a dehydration reaction, and the ginkgolide K is obtained through separation and purification. The method for preparing the ginkgolide K is easy to operate; meanwhile, the high yield and the high purity are achieved, and convenience is brought to industrialization large-scale production. (please see the specification for the formula).

A concise synthesis of ginkgolide M, a minor component of a terpene trilactone fraction from Ginkgo biloba roots

Ginkgolide M (GM), which is found only in the roots of the Ginkgo biloba tree and is an inhibitor of ligand-operated ion channels in the central nervous system, has been prepared in three steps from 10-benzylginkgolide C, an intermediate generated during the isolation and separation of ginkgolides from Ginkgo biloba leaf extract. The described synthetic sequence can be applied to access GM derivatives for biological studies.