153587-32-7Relevant articles and documents
Synthesis of SB 222618. A potential PDE IV inhibitor
Conde, Jose J.,Mendelson, Wilford
, p. 811 - 814 (2007/10/03)
PDE IV inhibitor SB 222618 was prepared by regioselective S(N)2' addition of 9 to bromoallene 6a followed by a stereoselective borane reduction of 4 to afford 2 which by a palladium mediated coupling with 3, delivered SB 222618 (1) in good yield. (C) 2000 Elsevier Science Ltd.
Compounds useful for treating allergic or inflammatory diseases
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, (2008/06/13)
Novel cyclohexanes of Formulas (I) and (II) STR1 are described herein. They inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production; these compounds are also useful in the mediation or inhibition of enzymatic or catalytic activity of phosphodiesterase V.