1538580-30-1

Basic information

• Product Name: (Z)-2-(nitrooxy)ethyl 2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetate
• Synonyms: (Z)-2-(nitrooxy)ethyl 2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetate
• CAS NO: 1538580-30-1
• Molecular Weight: 429.469
• Mol File: 1538580-30-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-2-(nitrooxy)ethyl 2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-2-(nitrooxy)ethyl 2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetate(1538580-30-1)
• EPA Substance Registry System: (Z)-2-(nitrooxy)ethyl 2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetate(1538580-30-1)

Safety Data

• Hazardous Substances Data: 1538580-30-1(Hazardous Substances Data)

Upstream product

• 38194-50-2 Sulindac 
• 16051-48-2 2-(nitrooxy)ethan-1-ol 
• 49627-27-2 sulindac sulfide 

Relevant articles and documents

Synthesis and biological evaluation of nitric oxide-donating analogues of sulindac for prostate cancer treatment

A series of analogues of the non-steroidal anti-inflammatory drug (NSAID) sulindac 1 were synthesised tethered to nitric oxide (NO) donating functional groups. Sulindac shows antiproliterative effects against immortal PC3 cell lines. It was previously demonstrated that the effect can be enhanced when tethered to NO releasing groups such as nitrate esters, furoxans and sydnonimines. To explore this approach further, a total of fifty-six sulindac-NO analogues were prepared and they were evaluated as NO-releasing cytotoxic agents against prostate cancer (PCa) cell lines. Compounds 1k and 1n exhibited significant cytotoxic with IC50 values of 6.1 ± 4.1 and 12.1 ± 3.2 μM, respectively, coupled with observed nitric oxide release.