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CAS

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154-69-8

Tripelennamine hydrochloride, also known as PBZ, is a first-generation antihistamine that is well absorbed when given orally. It is a white crystalline powder or solid with a bitter taste, which darkens slowly on exposure to light. The compound is soluble in water and alcohol, has a pKa of about 9, and exhibits neutral to litmus solutions. Tripelennamine hydrochloride is effective in treating various conditions and may have fewer side reactions compared to other antihistamines, although drowsiness may occur.

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  • 154-69-8 Structure

  • Basic information

    1. Product Name: TRIPELENNAMINE HYDROCHLORIDE
    2. Synonyms: 2-(benzyl(2-(dimethylamino)ethyl)amino)-pyridinmonohydrochloride;2-ethanediamine,n,n-dimethyl-n’-(phenylmethyl)-n’-2-pyridinyl-monohydroc;dehistin;dehistinmonohydrochloride;n(sup1)-alpha-pyridyl-n(sup1)-benzyl-n,n-dimethylethylenediaminemonohydro;n,n-dimethyl-n’-(2-pyridyl)-n’-benzylethylenediaminehydrochloride;n-benzyl-n’,n’-dimethyl-n-(2-pyridyl)-ethylenediaminhydrochloride;n-benzyl-n’,n’-dimethyl-n-2-pyridyl-ethylenediaminehydrochloride
    3. CAS NO:154-69-8
    4. Molecular Formula: C16H22ClN3
    5. Molecular Weight: 291.82
    6. EINECS: 205-833-5
    7. Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical raw material;API
    8. Mol File: 154-69-8.mol

  • Chemical Properties

    1. Melting Point: 192-193℃
    2. Boiling Point: 387.8 °C at 760 mmHg
    3. Flash Point: 188.3 °C
    4. Appearance: White solid
    5. Density: 1.20
    6. Vapor Pressure: 3.21E-06mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: Refrigerator
    9. Solubility: N/A
    10. CAS DataBase Reference: TRIPELENNAMINE HYDROCHLORIDE(CAS DataBase Reference)
    11. NIST Chemistry Reference: TRIPELENNAMINE HYDROCHLORIDE(154-69-8)
    12. EPA Substance Registry System: TRIPELENNAMINE HYDROCHLORIDE(154-69-8)

  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22-36/37/38
    3. Safety Statements: 26-36
    4. WGK Germany: 3
    5. RTECS: US3150000
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 154-69-8(Hazardous Substances Data)

154-69-8 Usage

Uses

Used in Pharmaceutical Industry:
Tripelennamine hydrochloride is used as an antihistamine for the treatment of various allergic conditions such as asthma, hay fever, and urticaria. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Used in Drug Delivery Systems:
While the provided materials do not specifically mention drug delivery systems for Tripelennamine hydrochloride, it can be inferred that the compound may be utilized in developing novel drug delivery systems to enhance its efficacy and bioavailability in treating allergic conditions. This could involve the use of various carriers and formulations to improve the compound's delivery and therapeutic outcomes.

Air & Water Reactions

Water soluble.

Reactivity Profile

TRIPELENNAMINE HYDROCHLORIDE behaves as a weak organic acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.

Fire Hazard

Flash point data for TRIPELENNAMINE HYDROCHLORIDE are not available; however, TRIPELENNAMINE HYDROCHLORIDE is probably combustible.

Veterinary Drugs and Treatments

Antihistamines are used in veterinary medicine to reduce or help prevent histamine mediated adverse effects. Tripelennamine has been used as a CNS stimulant in “Downer cows” when administered slow IV.

Check Digit Verification of cas no

The CAS Registry Mumber 154-69-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,5 and 4 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 154-69:
(5*1)+(4*5)+(3*4)+(2*6)+(1*9)=58
58 % 10 = 8
So 154-69-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H21N3.ClH/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15;/h3-11H,12-14H2,1-2H3;1H

154-69-8 Well-known Company Product Price

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  • Sigma-Aldrich

  • (T7511)  Tripelennaminehydrochloride  analytical standard

  • 154-69-8

  • T7511-25G

  • 492.57CNY

  • Detail

  • USP

  • (1695004)  Tripelennaminehydrochloride  United States Pharmacopeia (USP) Reference Standard

  • 154-69-8

  • 1695004-200MG

  • 4,326.66CNY

  • Detail

154-69-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name TRIPELENNAMINE HYDROCHLORIDE

1.2 Other means of identification

Product number -
Other names piristin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:154-69-8 SDS

154-69-8Synthetic route

hydrogenchloride
7647-01-0

hydrogenchloride

cobalt(II) chloride hexahydrate

cobalt(II) chloride hexahydrate

tripelennamine hydrochloride
154-69-8

tripelennamine hydrochloride

N-benzyl-N',N'-dimethyl-N-(2-pyridinio)-1,2-ethanediammonium tetrachlorocobaltate(II)
220156-62-7

N-benzyl-N',N'-dimethyl-N-(2-pyridinio)-1,2-ethanediammonium tetrachlorocobaltate(II)

Conditions
ConditionsYield
In hydrogenchloride equimolar amts. of CoCl2 and ligand, 6 M HCl; crystn. overnight, washing (EtOH), recrystn. (MeCN, room temp., slow evapn);
tripelennamine hydrochloride
154-69-8

tripelennamine hydrochloride

cucurbit[7]uril

cucurbit[7]uril

tripelennamine monohydrochloride-cucurbit[7]uril 1:1 complex

tripelennamine monohydrochloride-cucurbit[7]uril 1:1 complex

Conditions
ConditionsYield
In water pH=8;

154-69-8Upstream product

154-69-8Related news

Electro‐oxidation and Determination of TRIPELENNAMINE HYDROCHLORIDE (cas 154-69-8) at MWCNT‐CTAB Modified Glassy Carbon Electrode09/28/2019

An electrochemical method for the determination of tripelennamine hydrochloride (TPA) using cetyltrimethylammoniumbromide‐multiwalled carbon nanotubes modified glassy carbon electrode (MWCNT‐CTAB/GCE) was developed. Because of good electrical conductivity of MWCNT and catalytic behavior of CTA...detailed

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