15516-47-9

Basic information

• Product Name: 4-Methyl Phenoxy Acetyl Chloride
• Synonyms: 4-Methyl Phenoxy Acetyl Chloride;acetyl chloride, (4-methylphenoxy)-;2-(4-methylphenoxy)acetyl chloride;2-(4-methylphenoxy)ethanoyl chloride
• CAS NO: 15516-47-9
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.61956
• Mol File: 15516-47-9.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 112 °C(Press: 12 Torr)
• Appearance: /
• Density: 1.193±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-Methyl Phenoxy Acetyl Chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methyl Phenoxy Acetyl Chloride(15516-47-9)
• EPA Substance Registry System: 4-Methyl Phenoxy Acetyl Chloride(15516-47-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 15516-47-9(Hazardous Substances Data)

Usage

General Description

4-Methyl Phenoxy Acetyl Chloride is a chemical compound with the molecular formula C10H11ClO2. It is a derivative of acetyl chloride and is commonly used in organic synthesis. 4-Methyl Phenoxy Acetyl Chloride is a colorless liquid with a pungent odor and is highly reactive with water and air. It is commonly used as a reagent in the production of various pharmaceuticals, agrochemicals, and dyes. Additionally, it can be utilized as an intermediate in the synthesis of various other organic compounds. Overall, 4-Methyl Phenoxy Acetyl Chloride is a versatile and important chemical in the field of organic chemistry.

Upstream product

• 38768-63-7 methyl p-tolyloxyacetate 
• 106-44-5 p-cresol 
• 79-11-8 chloroacetic acid 
• 79-37-8 oxalyl dichloride 
• 940-64-7 2-(4-methylphenoxy)acetic acid 
• 1121-70-6 sodium 4-methylphenoxide 
• 67028-40-4 ethyl (4-methylphenoxy)acetate 

Downstream Products

• 72192-63-3 N-(5-phenyl-[1,3,4]thiadiazol-2-yl)-2-p-tolyloxy-acetamide 
• 65569-53-1 5-Chloro-N-(2-diethylamino-ethyl)-2-methoxy-4-(2-p-tolyloxy-acetylamino)-benzamide 
• 86148-97-2 p-Tolyloxy-thioacetic acid S-(8-bromo-4-oxo-3-p-tolyl-3,4-dihydro-quinazolin-2-yl) ester 
• 84496-28-6 2-(2-p-Tolyloxy-acetyl)-naphtho[1,2-d]oxazole-5-sulfonic acid 
• 86148-96-1 p-Tolyloxy-thioacetic acid S-[8-bromo-3-(4-bromo-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-yl] ester 
• 61057-54-3 (2-p-Tolyloxy-acetylamino)-acetic acid 
• 61057-55-4 2-(2-p-Tolyloxy-acetylamino)-propionic acid 
• 406701-78-8 (S)-4-Benzyl-3-[(4-methylphenoxy)acetyl]oxazolidin-2-one 
• 13910-68-4 4-(p-Tolyloxy-acetoxy)-cumarin 
• 41648-61-7 10-p-tolyloxyacetyl-10H-phenothiazine 

Relevant articles and documents

Photoassisted Synthesis of Complex Molecular Architectures: Dearomatization of Benzenoid Arenes with Aza-o-xylylenes via an Unprecedented [2+4] Reaction Topology

A new method was developed for the photoinduced dearomatization of arenes through an intramolecular cycloaddition with aza-o-xylylenes generated by excited-state intramolecular proton transfer (ESIPT) in the readily available photoprecursors. The [2+4] topology of this cycloaddition is unprecedented for photo-dearomatizations of benzenoid aromatic carbocycles. It provides rapid access to novel heterocycles, cyclohexadieno-oxazolidino-quinolinols, as valuable synthons for a broad range of post-photochemical transformations. I'm so excited: Photoinduced dearomatization of arenes was achieved through intramolecular cycloaddition with aza-o-xylylenes generated by excited-state intramolecular proton transfer in the readily available photoprecursors. The [2+4] topology of this cycloaddition is unprecedented for photo-dearomatizations of benzenoid aromatic carbocycles and produces the novel heterocycles cyclohexadieno-oxazolidino-quinolinols.

Design and Synthesis of Novel 4-Hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one Derivatives for Use as Herbicides and Evaluation of Their Mode of Action

In order to develop a novel herbicide containing the β-triketone motif, a series of 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one derivatives were designed and synthesized. The bioassay results showed that compound II15 had good pre-emergent herbicidal activity even at a dosage of 187.5 g ha-1. Moreover, compound II15 showed a broader spectrum of weed control when compared with a commercial herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), and displayed good crop safety to Triticum aestivum L. and Zea mays Linn. when applied at 375 g ha-1 under pre-emergence conditions, which indicated its great potential as a herbicide. More importantly, studying the molecular mode of action of compound II15 revealed that the novel triketone structure is a proherbicide of its corresponding phenoxyacetic acid auxin herbicide, which has a herbicidal mechanism similar to that of 2,4-D. The present work indicates that the 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one motif may be a potential lead structure for further development of novel auxin-type herbicides.

Isoflavone amide derivatives, their preparation method and medical use

The invention belongs to the field of medicinal chemistry, and relates to derivatives of isoflavones amides, as well as a preparation method and medical application of derivatives, in particular to the derivatives of the isoflavones amides with the general formula of (I) shown as the specification, the preparation method and the medical application of the derivatives, particularly the application of the derivatives of the isoflavones amides serving as medicaments for preventing or treating hyperlipemia, adiposis or type-II diabetes.