155392-50-0

Basic information

• Product Name: Ethanone, 2-(1,1-dioxido-4-thiomorpholinyl)-1-phenyl-
• CAS NO: 155392-50-0
• Molecular Formula: C12H15NO3S
• Molecular Weight: 253.322
• Mol File: 155392-50-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-(1,1-dioxido-4-thiomorpholinyl)-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-(1,1-dioxido-4-thiomorpholinyl)-1-phenyl-(155392-50-0)
• EPA Substance Registry System: Ethanone, 2-(1,1-dioxido-4-thiomorpholinyl)-1-phenyl-(155392-50-0)

Safety Data

• Hazardous Substances Data: 155392-50-0(Hazardous Substances Data)

Upstream product

• 39093-93-1 thiomorpholine 1,1-dioxide 
• 532-27-4 1-chloroacetophenone 

Downstream Products

• 155392-51-1 1-phenyl-2-(S,S-dioxothiomorpholino)ethylamine 

Relevant articles and documents

Benzoxazolamines and Benzothiazolamines: Potent, Enantioselective Inhibitors of Leukotriene Biosynthesis with a Novel Mechanism of Action

A series of benzoxazolamine and benzothiazolamine analogs that inhibit leukotriene (LT) biosynthesis are described.The initial lead, (S)-N-(benzothiazol-2-yl)phenylalanine ethyl ester (5a), was discovered in a screening program for inhibition of Ca-ionophore-A23187-induced LTB4 release in human polymorphonuclear leukocytes (IC50 0.23 μM).Through structural modification, it was determined that hydrophobic substituents in the 5-position and replacement of the phenyl ring of phenylalanine with a cyclohexyl group greatly enhance potency.Several ester bioisosteres that retain potency and enantiomeric selectivity are described.Lead optimization culminated in (S)-N--5-methyl-2-benzoxazolamine (43b), IC50 0.001 μM.The compounds described are not inhibitors of 5-lipoxygenase but, rather, act at the level of arachidonic acid release.